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Eighteen children underwent CPB surgery of ventricular left-to-right shunts at the mean age of 6 mo, while off-pump surgery (aortic coarctectomy) was undertaken at the mean age of 10 days in 12 children. After CPB surgery, both left anterior descending coronary artery mean diameter and basal CF increased from 1.7 \u00b1 0.3 to 2.1 \u00b1 0.4 mm ( P = 0.001) and 27 \u00b1 10 to 47 \u00b1 15 ml\/min ( P = 0.0001), respectively. These two coronary variables decreased after off-pump coarctectomy: left anterior descending coronary artery mean diameter from 1.8 \u00b1 0.1 to 1.7 \u00b1 0.1 mm ( P = 0.06), and CF from 44 \u00b1 12 to 25 \u00b1 8 ml\/min ( P = 0.001). The findings are in keeping with the hypothesis that the previously reported impairment of coronary flow reserve after CPB surgery could be due to increase in basal coronary flow after CPB. Off-pump coarctectomy seems to have little impact on CF, as the postsurgical decline in flow in these patients seems to relate to the reduction in cardiac pressure afterload. <\/jats:p>","DOI":"10.1152\/ajpheart.00025.2007","type":"journal-article","created":{"date-parts":[[2007,5,4]],"date-time":"2007-05-04T21:04:22Z","timestamp":1178312662000},"page":"H1138-H1143","source":"Crossref","is-referenced-by-count":13,"title":["Effects of cardiopulmonary bypass surgery on coronary flow in children assessed with transthoracic Doppler echocardiography"],"prefix":"10.1152","volume":"293","author":[{"given":"Elhadi H.","family":"Aburawi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ansgar","family":"Berg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petru","family":"Liuba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erkki","family":"Pesonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01907955"},{"key":"R2","unstructured":"British Standards Institution. 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