{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:07:29Z","timestamp":1790564849598,"version":"4.1.0"},"reference-count":60,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL160969"],"award-info":[{"award-number":["R01HL160969"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DBI-2349224"],"award-info":[{"award-number":["DBI-2349224"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:p>Recent studies increasingly highlight profound metabolic remodeling within the HFpEF heart; however, it remains unclear if this is an intrinsic or systemic phenomenon. In the present study, we identify dicarbonyl and glycative stress as key drivers of mitochondrial dysfunction in an ANGII\/PE mouse model with HFpEF phenotype independent of systemic metabolic disease. These findings reveal a previously unrecognized metabolic-mitochondrial axis and suggest dicarbonyl detoxification and mitochondrial antiglycation as potential therapeutic targets.<\/jats:p>","DOI":"10.1152\/ajpheart.00029.2026","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T17:22:23Z","timestamp":1776792143000},"page":"H1689-H1701","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Cardiac metabolic remodeling drives dicarbonyl stress-induced mitochondrial dysfunction in experimental heart failure with preserved ejection fraction"],"prefix":"10.1152","volume":"330","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1691-5112","authenticated-orcid":false,"given":"Ankit","family":"Aryal","sequence":"first","affiliation":[{"name":"Louisiana State University Health Science Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3582-1669","authenticated-orcid":false,"given":"Parnia","family":"Mobasheran","sequence":"additional","affiliation":[{"name":"Louisiana State University Health Science Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luther","family":"Bishop","sequence":"additional","affiliation":[{"name":"Louisiana State University Health Science Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabyasachi","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Louisiana State University Health Science Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0018-6909","authenticated-orcid":false,"given":"Scott","family":"Jennings","sequence":"additional","affiliation":[{"name":"Louisiana State University Health Science Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7024-5693","authenticated-orcid":false,"given":"Huijing","family":"Xia","sequence":"additional","affiliation":[{"name":"Louisiana State University Health Science Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7290-0786","authenticated-orcid":false,"given":"Eric","family":"Lazartigues","sequence":"additional","affiliation":[{"name":"Louisiana State University Health Science Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6024-2517","authenticated-orcid":false,"given":"Qinglin","family":"Yang","sequence":"additional","affiliation":[{"name":"Louisiana State University Health Science Center","place":["United States"]},{"name":"Louisiana State University Health Science Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2010.165"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvad026"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.000000000000075"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2024.07.001"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.031622"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2018.03.006"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2020.07.016"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9113582"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2024.102968"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2025.1641023"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.113.302095"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.668665"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.189951"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)91838-l"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.86.6.1810"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2016.06.009"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1994.267.2.H742"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.109.888479"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-013-0358-9"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-025-02778-6"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3390\/genes16060647"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2023.111870"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00038.2023"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1002\/9780470942390.mo150182"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae253"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btz931"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1126\/science.1230381"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00278.2025"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn213"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2009.03.011"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2022.2067479"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2012.07.015"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3390\/cells12091273"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2019.03.020"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.109.153213"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2008.12.017"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra063052"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24405"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn301"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23020996"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25021211"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00121.2025"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103184"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.673917"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-023-00863-2"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1104\/pp.110.167569"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.105716"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.11.032"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-5679-0_5"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(02)73901-5"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22882-x"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6626484"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0718-3"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13067"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1515\/dmdi.2008.23.1-2.13"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.80.6.1795"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201643354"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01543"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.112.972828"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2017.65"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00029.2026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:20:58Z","timestamp":1777908058000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00029.2026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,1]]},"references-count":60,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5,1]]}},"alternative-id":["10.1152\/ajpheart.00029.2026"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00029.2026","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,1]]},"assertion":[{"value":"2026-01-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-29","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}