{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:54:58Z","timestamp":1790650498079,"version":"4.1.0"},"reference-count":86,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["DK106102"],"award-info":[{"award-number":["DK106102"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Canada 150 Research Program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2019,5,1]]},"abstract":"<jats:p>Sex differences in blood pressure and the prevalence of hypertension are found in humans and animal models. Moreover, there has been a recent explosion of data concerning sex differences in nitric oxide, the renin-angiotensin-aldosterone system, inflammation, and kidney function. These data have the potential to reveal the mechanisms underlying male-female differences in blood pressure control. To elucidate the interactions among the multitude of physiological processes involved, one may apply computational models. In this review, we describe published computational models that represent key players in blood pressure regulation, and highlight sex-specific models and their findings.<\/jats:p>","DOI":"10.1152\/ajpheart.00035.2019","type":"journal-article","created":{"date-parts":[[2019,3,15]],"date-time":"2019-03-15T13:33:18Z","timestamp":1552656798000},"page":"H1113-H1123","source":"Crossref","is-referenced-by-count":37,"title":["Understanding sex differences in long-term blood pressure regulation: insights from experimental studies and computational modeling"],"prefix":"10.1152","volume":"316","author":[{"given":"Sameed","family":"Ahmed","sequence":"first","affiliation":[{"name":"Department of Applied Mathematics, University of Waterloo, Waterloo, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Applied Mathematics, University of Waterloo, Waterloo, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Leete","sequence":"additional","affiliation":[{"name":"Computational Biology and Bioinformatics Program, Duke University, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita T.","family":"Layton","sequence":"additional","affiliation":[{"name":"Department of Applied Mathematics, University of Waterloo, Waterloo, Ontario, Canada"},{"name":"School of Pharmacy, University of Waterloo, Waterloo, Ontario, Canada"},{"name":"Departments of Mathematics, Biomedical Engineering, and Medicine, Duke University, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-115-4-287"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1530\/acta.0.1240091"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.228619"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2004.06.021"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.2-208.v1"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1042\/cs0470435"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00174.2014"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.02036.x"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c120002"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2013.00201"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00482.2016"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(91)90428-E"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.19.5.456"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1177\/1470320314523659"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199310000-00005"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.08750812"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00158.2014"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114102"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(01)00479-5"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00149.2014"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.33.1.323"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.31.1.90"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-198909000-00005"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.06602"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2008.185"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1007\/s10441-010-9098-5"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.34.030172.000305"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00039.2013"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.166827"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-012-0319-y"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/sj.clpt.6100495"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2007.02.001"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1007\/BF02363132"},{"key":"B33","first-page":"S59","volume":"42","author":"Johnston CI","year":"1993","journal-title":"Kidney Int Suppl"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-005-5976-4"},{"key":"B35","first-page":"222","volume":"40","author":"Katz AI","year":"1967","journal-title":"Yale J Biol Med"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/5.9.616"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(01)02164-1"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2010.00854.x"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00204.2010"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00294.2016"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1006108"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1007\/s11538-008-9370-x"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00293.2016"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00007.2015"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2018.11.002"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.compchemeng.2018.02.009"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00171.2018"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-7415-0_20"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1927.83.1.196"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.12.034"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2016.06.008"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.04593"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00260.x"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-014-0013-7"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1999.277.3.F437"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00500.2013"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1988.254.2.F223"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.9.2.172"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.30.5.1238"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01277.2007"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.03581"},{"key":"B62","unstructured":"Pourteyron P. Etude comparative sur l'anatomie et la pathologie des deux reins. (PhD thesis), Paris: 1872."},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e3182676f06."},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.35.1.480"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-85729-832-4_4"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1988.206"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.3317\/jraas.2006.015"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-007-0308-1"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00450.2011"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1186\/2042-6410-3-7"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.1.39"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00649.2013"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.01.020"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00864.2007"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00526.2009"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1210\/en.2002-221045"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1098\/rsta.2008.0079"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.03512"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00175.2017"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1007\/BF02455306"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2017030295"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.10052"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00505.2014"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1016\/0895-7061(95)00216-2"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00013.2013"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00035.2019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T13:21:01Z","timestamp":1567948861000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpheart.00035.2019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,1]]},"references-count":86,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5,1]]}},"alternative-id":["10.1152\/ajpheart.00035.2019"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00035.2019","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,1]]}}}