{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:47:51Z","timestamp":1787017671099,"version":"build-2736575974"},"reference-count":60,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R15 HL165328-01"],"award-info":[{"award-number":["R15 HL165328-01"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["2024 Student Scholarship"],"award-info":[{"award-number":["2024 Student Scholarship"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:p>Postmenopause is a critical period in women\u2019s lives marked by metabolic and vascular changes that remain poorly understood. Asprosin, a novel adipokine, is linked to metabolic disorders and cardiovascular risk. In long-term OVX mice, circulating asprosin levels were elevated and associated with weight gain and arterial stiffness. Exogenous asprosin was associated with vasoconstriction, supporting its potential as a biomarker and a candidate for further mechanistic investigation in postmenopausal vasculometabolic regulation.<\/jats:p>","DOI":"10.1152\/ajpheart.00042.2026","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T21:11:01Z","timestamp":1773781861000},"page":"H1293-H1301","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Elevated asprosin in postmenopause is associated with vasculometabolic complications"],"prefix":"10.1152","volume":"330","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1449-9391","authenticated-orcid":false,"given":"Nefia","family":"Chacko","sequence":"first","affiliation":[{"name":"New York Institute of Technology","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohit","family":"Shah","sequence":"additional","affiliation":[{"name":"New York Institute of Technology","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2157-6551","authenticated-orcid":false,"given":"Reia","family":"Thomas","sequence":"additional","affiliation":[{"name":"New York Institute of Technology","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Jude-Aspiras","sequence":"additional","affiliation":[{"name":"New York Institute of Technology","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5057-4772","authenticated-orcid":false,"given":"Akinobu","family":"Watanabe","sequence":"additional","affiliation":[{"name":"New York Institute of Technology","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2428-6018","authenticated-orcid":false,"given":"Maria Alicia","family":"Carrillo-Sepulveda","sequence":"additional","affiliation":[{"name":"New York Institute of Technology","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.70272"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12100954"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000001136"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-025-01343-6"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2022.03.002"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1530\/EC-21-0537"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000912"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1177\/0148607108325251"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines13102376"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2023.102348"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-024-01561-z"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-024-01462-1"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e318240f6f3"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000950"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3109\/13697137.2012.707385"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare4030042"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.04.023"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199906103402306"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.236687"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2012.00165"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3390\/nu15020444"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1007\/1-4020-5688-5_3"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2020.00022"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2013.33181"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2022.07.008"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.02.063"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9471583"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1097\/j.pbj.0000000000000108"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2017.10.034"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/2521096"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.02385"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0245166"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.123.22024"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2024.105673"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.618037"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0100-19.2019"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.119.260471"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-62562-2"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.09.034"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2018.03.011"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-020-03879-4"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.cdtm.2015.02.006"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1007\/s12291-023-01163-y"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1080\/17446651.2025.2510595"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4432"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-023-01266-9"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3390\/nu17203238"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.1003118"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.03.008"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.27832"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.24-0442"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2023.0383"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1002\/oby.23656"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-022-01457-0"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00630.2025"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/204390"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.37.5.1199"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.319424"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e31659"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-015-1318-7"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00042.2026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T15:46:07Z","timestamp":1775576767000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00042.2026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,1]]},"references-count":60,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4,1]]}},"alternative-id":["10.1152\/ajpheart.00042.2026"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00042.2026","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,1]]},"assertion":[{"value":"2026-01-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-02","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}