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When studied at their respective in vivo pressures, the myogenic index (instantaneous slope of the active pressure-diameter curve) of arterioles from 42\u201349-day-old rats was more negative than that of arterioles from 21\u201328-day-old rats, indicating greater myogenic responsiveness. Endothelial denudation, or prostaglandin H<jats:sub>2<\/jats:sub>(PGH<jats:sub>2<\/jats:sub>)\/thromboxane A<jats:sub>2<\/jats:sub>(TxA<jats:sub>2<\/jats:sub>) receptor antagonism without denudation, significantly reduced the myogenic responsiveness of arterioles from the older rats over a wide range of pressures but had no consistent effects on the myogenic responsiveness of arterioles from the younger rats. The heme oxygenase inhibitor chromium (III) mesoporphyrin IX chloride had no effect on the myogenic activity of arterioles from either age group. These findings indicate that microvascular growth in young animals is accompanied by an increase in the myogenic behavior of arterioles, possibly because PGH<jats:sub>2<\/jats:sub>or TxA<jats:sub>2<\/jats:sub>assumes a role in reinforcing myogenic activity over this period. As a result, the relative contribution of myogenic activity to blood flow regulation in skeletal muscle may increase during rapid juvenile growth.<\/jats:p>","DOI":"10.1152\/ajpheart.00053.2008","type":"journal-article","created":{"date-parts":[[2008,3,29]],"date-time":"2008-03-29T12:13:50Z","timestamp":1206792830000},"page":"H2344-H2351","source":"Crossref","is-referenced-by-count":7,"title":["Increased myogenic responsiveness of skeletal muscle arterioles with juvenile growth"],"prefix":"10.1152","volume":"294","author":[{"given":"Julie Balch","family":"Samora","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jefferson C.","family":"Frisbee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew 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