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This study tested the hypothesis that attenuating hypertension before pregnancy and through the placentation period via 1,3-butanediol prevents the onset of preeclampsia in female Dahl salt-sensitive (SS\/Jr) rats. We found that 1,3-butanediol significantly lowered blood pressure and improved uterine artery resistance in pregnant Dahl salt-sensitive rats, with no observable adverse fetal effects. 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