{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:58:57Z","timestamp":1740139137285,"version":"3.37.3"},"reference-count":51,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/100015015","name":"South Australian Government","doi-asserted-by":"crossref","award":["SA Early to Mid Career Fellowship"],"award-info":[{"award-number":["SA Early to Mid Career Fellowship"]}],"id":[{"id":"10.13039\/100015015","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004267","name":"Royal Adelaide Hospital","doi-asserted-by":"publisher","award":["AR Clarkson Award"],"award-info":[{"award-number":["AR Clarkson Award"]}],"id":[{"id":"10.13039\/501100004267","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2019,10,1]]},"abstract":"<jats:p>A large body of evidence demonstrates an independent association between arterial stiffness and prospective risk of cardiovascular events. A reduction in coronary perfusion is presumed to underscore this association; however, studies confirming this are lacking. This study compared invasive measures of coronary blood flow (CBF) with cardiac magnetic resonance (CMR)-derived aortic distensibility (AD). Following coronary angiography, a Doppler FloWire and infusion microcatheter were advanced into the study vessel. Average peak velocity (APV) was acquired at baseline and following intracoronary adenosine to derive coronary flow velocity reserve (CFVR\u2009=\u2009hyperemic APV\/resting APV) and CBF [\u03c0 \u00d7 (diameter)<jats:sup>2<\/jats:sup>\u00d7 APV \u00d7 0.125]. Following angiography, patients underwent CMR to evaluate distensibility at the ascending aorta (AA), proximal descending aorta (PDA) and distal descending aorta (DDA). Fifteen participants (53\u2009\u00b1\u200913 yr) with minor epicardial disease (maximum stenosis &lt;30%) were enrolled. Resting CBF was 44.1\u2009\u00b1\u200911.9 mL\/min, hyperemic CBF was 143.8\u2009\u00b1\u200937.4 mL\/min, and CFVR was 3.15\u2009\u00b1\u20090.48. AD was 3.89\u2009\u00b1\u20091.72\u00b710<jats:sup>\u22123<\/jats:sup>mmHg<jats:sup>\u22121<\/jats:sup>at the AA, 4.08\u2009\u00b1\u20091.80\u00b710<jats:sup>\u22123<\/jats:sup>mmHg<jats:sup>\u22121<\/jats:sup>at the PDA, and 4.42\u2009\u00b1\u20091.67\u00b710<jats:sup>\u22123<\/jats:sup>mmHg<jats:sup>\u22121<\/jats:sup>at the DDA. All levels of distensibility correlated with resting CBF ( R<jats:sup>2<\/jats:sup>= 0.350\u20130.373, P &lt; 0.05), hyperemic CBF ( R<jats:sup>2<\/jats:sup>= 0.453\u20130.464, P &lt; 0.01), and CFVR ( R<jats:sup>2<\/jats:sup>= 0.442\u20130.511, P &lt; 0.01). This study demonstrates that hyperemic and, to a lesser extent resting CBF, are significantly associated with measures of aortic stiffness in patients with only minor angiographic disease. These findings provide further in vivo support for the observed prognostic capacity of large artery function in cardiovascular event prediction.<\/jats:p><jats:p>NEW &amp; NOTEWORTHY Cardiac magnetic resonance-derived aortic distensibility is associated with invasive measures of coronary blood flow. Large artery function is more strongly correlated with hyperemic than resting blood flow. Increased stiffness may represent a potential target for novel antianginal medications.<\/jats:p>","DOI":"10.1152\/ajpheart.00067.2019","type":"journal-article","created":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T15:23:32Z","timestamp":1566573812000},"page":"H811-H819","source":"Crossref","is-referenced-by-count":8,"title":["Aortic distensibility is associated with both resting and hyperemic coronary blood flow"],"prefix":"10.1152","volume":"317","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0990-2548","authenticated-orcid":false,"given":"Adam J.","family":"Nelson","sequence":"first","affiliation":[{"name":"Department of Cardiology, Royal Adelaide Hospital, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rishi","family":"Puri","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, and Cleveland Clinic Coordinating Center for Clinical Research (C5R), Cleveland Clinic, Cleveland, 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