{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T20:31:19Z","timestamp":1789072279930,"version":"build-2803163510"},"reference-count":40,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL142770"],"award-info":[{"award-number":["R01 HL142770"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:p>Obesity and insulin resistance accelerate arterial stiffening and hypertension, increasing cardiovascular risk. Activation of the epithelial sodium channel (ENAC) contributes to vascular stiffening in preclinical models, yet the vascular effects of ENAC inhibition in adults with obesity and insulin resistance remain poorly characterized. Here, we demonstrate that low-dose amiloride reduces blood pressure and improves arterial stiffness in adults with overweight or obesity and features of metabolic syndrome, without major safety concerns.<\/jats:p>","DOI":"10.1152\/ajpheart.00084.2026","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T17:01:11Z","timestamp":1773334871000},"page":"H1274-H1282","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["ENAC blockade reduces blood pressure and arterial stiffness in adults with obesity and insulin resistance"],"prefix":"10.1152","volume":"330","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7944-4936","authenticated-orcid":false,"given":"Jaume","family":"Padilla","sequence":"first","affiliation":[{"name":"University of Missouri","place":["United States"]},{"name":"University of Missouri","place":["United States"]},{"name":"Harry S. Truman Memorial Veterans Hospital","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4920-383X","authenticated-orcid":false,"given":"Francisco I.","family":"Ramirez-Perez","sequence":"additional","affiliation":[{"name":"University of Missouri","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Smith","sequence":"additional","affiliation":[{"name":"University of Missouri","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9877-683X","authenticated-orcid":false,"given":"Rogerio N.","family":"Soares","sequence":"additional","affiliation":[{"name":"Wayne State University","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mya","family":"Burken","sequence":"additional","affiliation":[{"name":"University of Missouri","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Uptergrove","sequence":"additional","affiliation":[{"name":"University of Missouri","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8383-8579","authenticated-orcid":false,"given":"Suhwon","family":"Lee","sequence":"additional","affiliation":[{"name":"University of Missouri","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6559-5717","authenticated-orcid":false,"given":"Luis A.","family":"Martinez-Lemus","sequence":"additional","affiliation":[{"name":"University of Missouri","place":["United States"]},{"name":"University of Missouri","place":["United States"]},{"name":"University of Missouri","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9341-404X","authenticated-orcid":false,"given":"Camila","family":"Manrique-Acevedo","sequence":"additional","affiliation":[{"name":"University of Missouri","place":["United States"]},{"name":"Harry S. Truman Memorial Veterans Hospital","place":["United States"]},{"name":"University of Missouri","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000973"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.030142"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00318.2010"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00413.2010"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00504.2025"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.118.11339"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00456"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1210\/en.2019-00483"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008167.pub3"},{"key":"B10","unstructured":"Urbaniak G. Research Randomizer. Version 4.0 ed (Online). http:\/\/www.randomizer.org\/2013."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.123.21618"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-022-00563-x"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00556.2024"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-024-01254-5"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.121.18772"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz350"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.6.1487"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0288"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v067.i01"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v082.i13"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-007-0341-0"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.111.199455"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1161\/01.Atv.0000160548.78317.29"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.109.914507"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.01445"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2023.104619"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(21)01921-8"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.03348"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.109.137653"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1001\/2012.jama.10503"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.013915"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1111\/apha.13189"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1111\/jch.12218"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.10.002"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00268.2023"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.123.20545"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2010.362"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1007\/bf00191913"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-26323-6"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01920-6"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00084.2026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T15:46:09Z","timestamp":1775576769000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00084.2026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,1]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4,1]]}},"alternative-id":["10.1152\/ajpheart.00084.2026"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00084.2026","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,1]]},"assertion":[{"value":"2026-02-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-14","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}