{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T13:13:19Z","timestamp":1779196399401,"version":"3.51.4"},"reference-count":42,"publisher":"American Physiological Society","issue":"6","funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["5I01BX001981"],"award-info":[{"award-number":["5I01BX001981"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007165","name":"University of Missouri","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007165","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Thomas W. Burns Research Endowment"}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:p>This study identifies transglutaminase 2 in myeloid cells as a key regulator of angiotensin II-induced vascular inflammation, aortic stiffening, and hypertension. Myeloid TG2 deletion restores the Treg-Th17 balance and suppresses Ang II-driven inflammatory signaling, revealing an immune-mediated mechanism linking renin-angiotensin-aldosterone system activation to vascular remodeling.<\/jats:p>","DOI":"10.1152\/ajpheart.00095.2026","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:10:21Z","timestamp":1777475421000},"page":"H1853-H1861","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Myeloid transglutaminase 2 regulates Treg-Th17 balance in a female model of angiotensin II-induced hypertension and vascular stiffening"],"prefix":"10.1152","volume":"330","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1989-7466","authenticated-orcid":false,"given":"Huma","family":"Naz","sequence":"first","affiliation":[{"name":"University of Missouri","place":["United States"]},{"name":"Harry S. Truman Memorial Veterans\u2019 Hospital","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3596-5481","authenticated-orcid":false,"given":"Emma","family":"Teixeiro","sequence":"additional","affiliation":[{"name":"University of Missouri","place":["United States"]},{"name":"University of Missouri","place":["United States"]},{"name":"University of Missouri","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9341-404X","authenticated-orcid":false,"given":"Camila","family":"Manrique-Acevedo","sequence":"additional","affiliation":[{"name":"University of Missouri","place":["United States"]},{"name":"Harry S. Truman Memorial Veterans\u2019 Hospital","place":["United States"]},{"name":"University of Missouri","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9205-1021","authenticated-orcid":false,"given":"Guido","family":"Lastra","sequence":"additional","affiliation":[{"name":"University of Missouri","place":["United States"]},{"name":"Harry S. Truman Memorial Veterans\u2019 Hospital","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.11.007"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.119.14240"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.886655"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-025-02229-5"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.124.23518"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpz018"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00431.2021"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2001122"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3390\/cells10071842"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000203503.82693.c1"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1009691"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.122.20601"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.588358"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1007\/BF01002772"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7113-8_26"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqac145"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3791\/50323"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.24727"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2016.00152"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01636"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.09.011"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2013.12.027"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707454"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1097\/01.mnh.0000203190.34643.d4"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-023-00964-1"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070657"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1172\/JCI74084"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae863"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(94)00531-1"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.173328"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvs422"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.109.145094"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1042\/cs20190682"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.12286"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvy164"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.109.137158"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.111.233262"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00456.2006"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.117.312153"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1097\/hjh.0000000000002328"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2022.09.007"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00095.2026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T12:54:17Z","timestamp":1779195257000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00095.2026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,1]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6,1]]}},"alternative-id":["10.1152\/ajpheart.00095.2026"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00095.2026","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,1]]},"assertion":[{"value":"2026-02-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-19","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}