{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:15:49Z","timestamp":1787800549337,"version":"build-2784847793"},"reference-count":84,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL132236"],"award-info":[{"award-number":["R01 HL132236"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["F31 HL140909"],"award-info":[{"award-number":["F31 HL140909"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL141855"],"award-info":[{"award-number":["R01 HL141855"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL138003"],"award-info":[{"award-number":["R01 HL138003"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL102298"],"award-info":[{"award-number":["R01 HL102298"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL138003"],"award-info":[{"award-number":["R01 HL138003"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005859","name":"Heart Rhythm Society","doi-asserted-by":"publisher","award":["Postdoctoral Clinical Research Award"],"award-info":[{"award-number":["Postdoctoral Clinical Research Award"]}],"id":[{"id":"10.13039\/100005859","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"<jats:p> Conduction slowing during acute ischemia creates an arrhythmogenic substrate. We have shown that extracellular ionic concentrations can alter conduction by modulating ephaptic coupling. Here, we demonstrate increased extracellular sodium and calcium significantly attenuate conduction slowing during no-flow ischemia. This effect was associated with selective widening of the perinexus, an intercalated disc nanodomain and putative cardiac ephapse. These findings suggest that acute changes in ephaptic coupling may serve as an adaptive response to ischemic stress. <\/jats:p>","DOI":"10.1152\/ajpheart.00112.2020","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T18:59:11Z","timestamp":1595012351000},"page":"H396-H409","source":"Crossref","is-referenced-by-count":28,"title":["Attenuating loss of cardiac conduction during no-flow ischemia through changes in perfusate sodium and calcium"],"prefix":"10.1152","volume":"319","author":[{"given":"Gregory S.","family":"Hoeker","sequence":"first","affiliation":[{"name":"Center for Heart and Reparative Medicine Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carissa C.","family":"James","sequence":"additional","affiliation":[{"name":"Center for Heart and Reparative Medicine Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, Virginia"},{"name":"Translational Biology, Medicine, and Health Graduate Program, Virginia Polytechnic Institute and State University, Roanoke, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison N.","family":"Tegge","sequence":"additional","affiliation":[{"name":"Virginia Tech Carilion School of Medicine, Roanoke, Virginia"},{"name":"Department of Statistics, Virginia Polytechnic Institute and State University, Blacksburg, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G.","family":"Gourdie","sequence":"additional","affiliation":[{"name":"Center for Heart and Reparative Medicine Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, Virginia"},{"name":"Virginia Tech Carilion School of Medicine, Roanoke, Virginia"},{"name":"Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4246-7904","authenticated-orcid":false,"given":"James W.","family":"Smyth","sequence":"additional","affiliation":[{"name":"Center for Heart and Reparative Medicine Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, Virginia"},{"name":"Virginia Tech Carilion School of Medicine, Roanoke, Virginia"},{"name":"Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Poelzing","sequence":"additional","affiliation":[{"name":"Center for Heart and Reparative Medicine Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, Virginia"},{"name":"Translational Biology, Medicine, and Health Graduate Program, Virginia Polytechnic Institute and State University, Roanoke, Virginia"},{"name":"Virginia Tech Carilion School of Medicine, Roanoke, Virginia"},{"name":"Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1983.sp014984"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.14.2.219"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1996.tb00496.x"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2006.03.005"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1109\/10.668746"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.87.8.656"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000558"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/0079-6107(81)90003-1"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1978.sp012466"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.70.1.149"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.66.6.1461"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.54.1.10"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01244.x"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-009-0473-1"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.26.5.565"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.56.2.217"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(74)90613-4"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.51.6.1003"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(77)80164-1"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00016"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00150.2017"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00857.2015"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00334"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00083.2018"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbiomolbio.2015.11.004"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-015-1698-0"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1996.tb00478.x"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.3.603"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.116.004400"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1126\/science.119.3085.200"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1951.165.3.505"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/28.12.1737"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1113\/JP275351"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.61.4.768"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.65.1.95"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13120"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108309"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199903000-00024"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1007042"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.49.5.1069"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.77.6.1385"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.51.5.614"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.60.2.397"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.11.035"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2003.026732"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.65.4.1029"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.76.5.1146"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2007.00123.x"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.73.1.189"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.61.2.271"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.68.1.255"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(85)90596-4"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2018.138"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2012.04.034"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10342"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1010154107"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2012.2226720"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2013.11.1117"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1991.261.6.H2008"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00441.2003"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.66.4.913"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.1.10"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.43.1.125"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.51.5.637"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.3791\/58311"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00398"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.49.4.901"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e10-06-0548"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2012.12.005"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2005.06.020"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0975fje"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.53.2.176"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.37610"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-014-1675-z"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-016-1861-2"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.3109\/15419061.2014.905932"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00868.2011"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1996.0012"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.01487"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2016.02.029"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1955.sp005379"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1063\/1.4999602"},{"key":"B84","first-page":"208","volume":"6","author":"Wilbrandt W","year":"1948","journal-title":"Helv Physiol Pharmacol Acta"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1007\/BF01869203"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00112.2020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T11:11:28Z","timestamp":1596539488000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00112.2020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,1]]},"references-count":84,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,8,1]]}},"alternative-id":["10.1152\/ajpheart.00112.2020"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00112.2020","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,1]]}}}