{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:33:39Z","timestamp":1790678019187,"version":"4.1.0"},"reference-count":183,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2018,11,1]]},"abstract":"<jats:p>Several interventions, such as ischemic preconditioning, remote pre\/perconditioning, or postconditioning, are known to decrease lethal myocardial ischemia-reperfusion injury. While several signal transduction pathways become activated by such maneuvers, they all have a common end point, namely, the mitochondria. These organelles represent an essential target of the cardioprotective strategies, and the preservation of mitochondrial function is central for the reduction of ischemia-reperfusion injury. In the present review, we address the role of mitochondria in the different conditioning strategies; in particular, we focus on alterations of mitochondrial function in terms of energy production, formation of reactive oxygen species, opening of the mitochondrial permeability transition pore, and mitochondrial dynamics induced by ischemia-reperfusion.<\/jats:p>","DOI":"10.1152\/ajpheart.00124.2018","type":"journal-article","created":{"date-parts":[[2018,7,13]],"date-time":"2018-07-13T14:43:36Z","timestamp":1531493016000},"page":"H1215-H1231","source":"Crossref","is-referenced-by-count":73,"title":["Mitochondria \u201cTHE\u201d target of myocardial conditioning"],"prefix":"10.1152","volume":"315","author":[{"given":"Kerstin","family":"Boengler","sequence":"first","affiliation":[{"name":"Institute of Physiology, Justus-Liebig Universit\u00e4t, Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnter","family":"Lochnit","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Justus-Liebig Universit\u00e4t, Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Schulz","sequence":"additional","affiliation":[{"name":"Institute of Physiology, Justus-Liebig Universit\u00e4t, Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.213116"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1401591111"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5416"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000151290.04952.3B"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e31816a1c1c"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2013.12.002"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/nature03434"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s12192-016-0682-8"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005427919188"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.2174\/0929867324666170608111917"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00733"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2007.08.004"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2011.01.009"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-010-0124-1"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2011.01516.x"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-55330-6_12"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-009-0007-5"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2013.00073"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.12.4695"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2005.07.014"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-014-0228-8"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.4161\/auto.6.4.11553"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000500"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1979.59.3.527"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00211.2007"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.110262"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e31823827cc"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.300559"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2005.01.007"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/nature13909"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1416230112"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2002.119490"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.1996.0342"},{"key":"B34","first-page":"357","volume":"255","author":"Crompton M","year":"1988","journal-title":"Biochem J"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1505489"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00267.2010"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021152709313"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01244.x"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2017.04.003"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M006825200"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-017-0501-2"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000461"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-016-0578-x"},{"key":"B44","doi-asserted-by":"crossref","first-page":"S469","DOI":"10.33549\/physiolres.932933","volume":"63","author":"Ferko M","year":"2014","journal-title":"Physiol Res"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.2811"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-017-0618-1"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1111\/iep.12170"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060967"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-017-0607-4"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.61.5.757"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-017-2034-7"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3109\/10715762.2015.1050013"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2016.61789"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.05.011"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1217823110"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01378.2006"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01019.2003"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2004.03.033"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.139"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18030614"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000126294.81407.7D"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-009-0010-x"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2016.5"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00678.2003"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.3892\/br.2015.485"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000181171.65293.65"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2017.07.005"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.305348"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-006-0589-0"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.255604"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2014.6238"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00747.2013"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020975"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.303356"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2016.6795"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2016.6635"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.034231"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2828(91)90185-O"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1172\/JCI19906"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.15190\/d.2017.1"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvt224"},{"key":"B82","doi-asserted-by":"crossref","first-page":"S611","DOI":"10.33549\/physiolres.933533","volume":"65","author":"Kancirov\u00e1 I","year":"2016","journal-title":"Physiol Res"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00933.2012"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00711.2002"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-55330-6_32"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.02.136"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12499"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-016-1922-6"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1016\/j.vascn.2018.01.004"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.305432"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1159\/000339043"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.2001.1357"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00253.2014"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0164066"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1124\/pr.115.012062"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2011.12.006"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2003.10.019"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2007.04.022"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq293"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1038\/nature22082"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-017-2618-6"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-007-0666-z"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13330"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M115.052894"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.3402\/jev.v5.32538"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2828(81)90213-3"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.10.052"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-55330-6_9"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvw004"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.11.198"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00024.2007"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-008-0731-2"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2016.12.020"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1038\/nature03317"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000103"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2014.11.005"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.906610"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-014-0460-x"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3245"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2009.02.017"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(85)90675-7"},{"key":"B122","doi-asserted-by":"crossref","first-page":"8731","DOI":"10.1016\/S0021-9258(19)75283-1","volume":"252","author":"Palmer JW","year":"1977","journal-title":"J Biol Chem"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1986.250.5.H741"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00911-10"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00833.2011"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000109416.56608.64"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2009.03.013"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-006-0584-5"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1126\/science.1135380"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa071142"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2006.03.010"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.87.3.893"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2012.05.090"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0167678"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.303822"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1126\/science.7892609"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00866.2004"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000230315.56904.de"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2017.06.011"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2012.02.004"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2017.0157"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2014.01.001"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2017.03.004"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00442.2002"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2007.041442"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-226225"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.306374"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2017.05.033"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.306878"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00693.2002"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.09.206"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1038\/srep13243"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-014-0433-x"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2017.04.008"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/287058"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu066"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M207217200"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2015.11.032"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01244.2003"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvv044"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2012.01.024"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2007.08.031"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1159\/000485399"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvv279"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.05.007"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13298"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2007.12.055"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-016-0531-z"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00276.2011"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.267"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1126\/science.1164551"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2003.10.008"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2015.02.015"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(96)00269-6"},{"key":"B175","first-page":"928","volume":"30","author":"Yang F","year":"2011","journal-title":"J Heart Lung Transplant"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2016.03.027"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.2659"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1515\/hsz-2012-0239"},{"key":"B179","first-page":"758684","volume":"2015","author":"Zhao X","year":"2015","journal-title":"Biomed Res Int"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8526561"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01064.2002"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.23781"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.5.1404"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00124.2018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T14:21:04Z","timestamp":1661610064000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpheart.00124.2018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,1]]},"references-count":183,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,11,1]]}},"alternative-id":["10.1152\/ajpheart.00124.2018"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00124.2018","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,1]]}}}