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The mechanistic links between fetal growth restriction and CVD include decreased arterial wall elastin-to-collagen ratio, endothelial dysfunction, and heightened renin-angiotensin-aldosterone system (RAAS). Systemic arterial thickness on fetal ultrasound and vascular changes in placental histopathology in growth restricted cohorts indicate fetal\/developmental origins of adult-onset circulatory diseases. Similar findings of impaired arterial compliance have been noticed across age groups (neonates through to adults). Such changes augment what occurs as \u201cnormal arterial aging,\u201d resulting in accelerated arterial aging. Data from animal models suggest that hypoxemia-associated vascular adaptations enacted in utero are region specific, reflecting long-term vascular pathology. In this review, we explore the influence of birthweight and prematurity on blood pressure and arterial stiffness, demonstrating impaired arterial dynamics in growth-restricted cohorts across age groups, explain how early arterial aging influences adult-onset CVDs, describe pathophysiology data from experimental models and finally, discuss interventions which may influence aging by way of altering various cellular and molecular mechanisms of arterial aging. Age-appropriate interventions which have noted efficacy include prolonged breastfeeding and high polyunsaturated fatty acids dietary intake. Targeting the RAAS seems a promising approach. New data indicate activation of sirtuin 1 and maternal resveratrol may have beneficial effects. <\/jats:p>","DOI":"10.1152\/ajpheart.00134.2023","type":"journal-article","created":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T16:07:25Z","timestamp":1684512445000},"page":"H89-H105","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Influence of accelerated arterial aging in growth-restricted cohorts on adult-onset cardiovascular diseases"],"prefix":"10.1152","volume":"325","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2600-7529","authenticated-orcid":false,"given":"Arvind","family":"Sehgal","sequence":"first","affiliation":[{"name":"Monash Newborn, Monash Children\u2019s Hospital, Melbourne, Victoria, Australia"},{"name":"Department of Paediatrics, Monash University, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1060-513X","authenticated-orcid":false,"given":"Beth J.","family":"Allison","sequence":"additional","affiliation":[{"name":"The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria, Australia"},{"name":"Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e0tima","family":"Crispi","sequence":"additional","affiliation":[{"name":"BCNatal-Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u), IDIBAPS, University of Barcelona, Barcelona, Spain"},{"name":"Centre for Biomedical Research on Rare Diseases (CIBER-ER), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Menahem","sequence":"additional","affiliation":[{"name":"Emeritus Head, Paediatric and Fetal Cardiac Units, Monash Health, Melbourne, Victoria, Australia"},{"name":"Murdoch Children\u2019s Research Institute, University of Melbourne, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.032582"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000558"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199212000-00004"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.298.6673.564"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(89)90710-1"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm042"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200018070-00002"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66419-7"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.06.030"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.05.076"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1042\/CS20070420"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000173522.98728.58"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1136\/jech.2008.084475"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.99"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2021.2537"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(00)90000-6"},{"key":"B17","unstructured":"Chow SSW, Creighton P, Chambers GM, Lui K. 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