{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T23:28:14Z","timestamp":1794266894659,"version":"4.9.0"},"reference-count":47,"publisher":"American Physiological Society","issue":"6","funder":[{"name":"Masonic Medical Research Institute","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:p>This study presents a genetic, cardiomyocyte-specific Ybx1 loss-of-function mouse model, addressing limitations of prior RNA interference (RNAi) approaches. Global YBX1 deletion causes embryonic lethality with severe cardiac malformations, whereas cardiomyocyte-specific deletion results in only transient embryonic noncompaction that resolves with normal adult heart structure and function. Cardiac function remained preserved for up to 11 mo, and although fibrosis-related genes were upregulated, no overt fibrotic phenotype was observed, supporting cardiomyocyte-targeted YBX1 reduction as a potentially safe therapeutic strategy.<\/jats:p>","DOI":"10.1152\/ajpheart.00135.2026","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T17:10:53Z","timestamp":1779210653000},"page":"H2014-H2024","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Myocardial YBX1 is dispensable for cardiac development and function"],"prefix":"10.1152","volume":"330","author":[{"given":"Elise V.","family":"Stanley","sequence":"first","affiliation":[{"name":"Masonic Medical Research Institute","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijie","family":"Han","sequence":"additional","affiliation":[{"name":"Masonic Medical Research Institute","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reaghan","family":"Sassower","sequence":"additional","affiliation":[{"name":"Masonic Medical Research Institute","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Gao","sequence":"additional","affiliation":[{"name":"Masonic Medical Research Institute","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2711-0069","authenticated-orcid":false,"given":"Chase W.","family":"Kessinger","sequence":"additional","affiliation":[{"name":"Masonic Medical Research Institute","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6232-3268","authenticated-orcid":false,"given":"Tongbin","family":"Wu","sequence":"additional","affiliation":[{"name":"Masonic Medical Research Institute","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M704672200"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.15.6.2972"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks579"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.19.5491"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M209145200"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1159\/000228079"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2009.12.024"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M212966200"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12092473"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-05-089151"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-1082"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.11.007"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3003175"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2006.01.008"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.11.4625-4637.2005"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M605948200"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020009676"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv779"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.02.053"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0353-2"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.067005"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25010401"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.124.070279"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-023-00996-1"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/20.4.797"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.758158"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/s44161-023-00344-5"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.038361"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.7150\/thno.35218"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.125.326948"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.20275"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.056666"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1010630"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1713763114"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaf237"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2015.00156"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/s0925-4773(03)00066-2"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2023.07.009"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2018.07.130"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-017-2737-0"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2022.914430"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2001.5334"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.007545"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/29.5.1200"},{"key":"B45","first-page":"1325","volume":"57","author":"Meyer-Kleine C","year":"1995","journal-title":"Am J Hum Genet"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.165860"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1161\/hh1301.092687"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00135.2026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T17:59:34Z","timestamp":1779991174000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00135.2026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,1]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6,1]]}},"alternative-id":["10.1152\/ajpheart.00135.2026"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00135.2026","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,1]]},"assertion":[{"value":"2026-02-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-25","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}