{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T03:23:02Z","timestamp":1778901782818,"version":"3.51.4"},"reference-count":47,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science (JSPS)","doi-asserted-by":"publisher","award":["23300275"],"award-info":[{"award-number":["23300275"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Nara Women's University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2018,2,1]]},"abstract":"<jats:p>We examined whether chronic estrogen replacement has an inhibitory effect on stress-induced pressor responses via activation of \u03b2<jats:sub>2<\/jats:sub>-adrenoceptor (AR) in peripheral arteries of ovariectomized rats. Female Wistar rats aged 9 wk were ovariectomized. After 4 wk, pellets containing either 17\u03b2-estradiol (E<jats:sub>2<\/jats:sub>) or placebo (Pla) were subcutaneously implanted into the rats. After 4 wk of treatment, rats underwent cage-switch stress, and, in a separate experiment, a subset received an infusion of isoproterenol (ISO) with or without pretreatment with the \u03b2<jats:sub>1<\/jats:sub>-AR blocker atenolol or the \u03b2<jats:sub>2<\/jats:sub>-AR blocker butoxamine. In addition, the isolated mesenteric artery was used to assess the concentration-related relaxing responses to ISO and the \u03b2<jats:sub>1<\/jats:sub>- or \u03b2<jats:sub>2<\/jats:sub>-AR mRNA level. The cage-switch stress-induced pressor response was significantly attenuated in the E<jats:sub>2<\/jats:sub>-treated group compared with the Pla-treated group. Pretreatment with atenolol reduced blood pressure responses in both groups. However, butoxamine enhanced the pressor response only in the E<jats:sub>2<\/jats:sub>-treated group, resulting in no difference between the two groups. In addition, the intravenous ISO-induced depressor response was significantly enhanced in the E<jats:sub>2<\/jats:sub>-treated group compared with the Pla-treated group. Furthermore, the difference in the depressor response was abolished by pretreatment with butoxamine but not by atenolol. In the isolated mesenteric artery, butoxamine caused a rightward shift in ISO-induced concentration-related relaxation in the E<jats:sub>2<\/jats:sub>-treated group. The \u03b2<jats:sub>2<\/jats:sub>-AR mRNA level in the mesenteric artery was higher in the E<jats:sub>2<\/jats:sub>-treated group than in the Pla-treated group. These results suggest that estrogen replacement attenuated the stress-induced pressor response probably by suppressing vasoconstriction via activation of \u03b2<jats:sub>2<\/jats:sub>-ARs in peripheral arteries of ovariectomized rats.<\/jats:p><jats:p>NEW &amp; NOTEWORTHY In this study, we show, for the first time, that estrogen replacement has an inhibitory effect on the psychological stress-induced pressor response through vasorelaxation via \u03b2<jats:sub>2<\/jats:sub>-adrenoceptors, probably due to overexpression of \u03b2<jats:sub>2<\/jats:sub>-adrenoceptor mRNA, in peripheral arteries of ovariectomized rats.<\/jats:p>","DOI":"10.1152\/ajpheart.00148.2017","type":"journal-article","created":{"date-parts":[[2017,10,14]],"date-time":"2017-10-14T01:10:33Z","timestamp":1507943433000},"page":"H213-H223","source":"Crossref","is-referenced-by-count":5,"title":["Estrogen replacement attenuates stress-induced pressor responses through vasorelaxation via \u03b2<sub>2<\/sub>-adrenoceptors 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