{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T04:16:46Z","timestamp":1788495406412,"version":"build-2803163510"},"reference-count":65,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["23POST1023125"],"award-info":[{"award-number":["23POST1023125"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R00-HL141698"],"award-info":[{"award-number":["R00-HL141698"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R56-HL165137"],"award-info":[{"award-number":["R56-HL165137"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["1R35-HL161249-01"],"award-info":[{"award-number":["1R35-HL161249-01"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:p>Atrial fibrillation is the most common cardiac rhythm disorder, and remodeling during atrial fibrillation is highly variable between patients. This study has defined the biophysical changes in contractility that occur in atrial fibrillation along with identifying potential molecular mechanisms that may drive this remodeling. This includes proteolysis of several myofilament proteins including titin, troponin I, myosin heavy chain, myosin binding protein C, and actinin, which is consistent with the observed contractile deficits.<\/jats:p>","DOI":"10.1152\/ajpheart.00148.2024","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T11:27:54Z","timestamp":1719574074000},"page":"H460-H472","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Proteolytic degradation of atrial sarcomere proteins underlies contractile defects in atrial fibrillation"],"prefix":"10.1152","volume":"327","author":[{"given":"Hannah E.","family":"Cizauskas","sequence":"first","affiliation":[{"name":"Department of Cell and Molecular Physiology, Loyola University Chicago, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9912-019X","authenticated-orcid":false,"given":"Hope V.","family":"Burnham","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Physiology, Loyola University Chicago, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azaria","family":"Panni","sequence":"additional","affiliation":[{"name":"Feinberg Cardiovascular and Renal Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Physiology, Loyola University Chicago, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9608-3004","authenticated-orcid":false,"given":"Alejandro","family":"Alvarez-Arce","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Physiology, Loyola University Chicago, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Therese","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Physiology, Loyola University Chicago, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly N.","family":"Araujo","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Physiology, Loyola University Chicago, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine E.","family":"Delligatti","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Physiology, Loyola University Chicago, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1129-748X","authenticated-orcid":false,"given":"Seby","family":"Edassery","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Physiology, Loyola University Chicago, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5192-2860","authenticated-orcid":false,"given":"Jonathan A.","family":"Kirk","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Physiology, Loyola University Chicago, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishi","family":"Arora","sequence":"additional","affiliation":[{"name":"Feinberg Cardiovascular and Renal Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6166-640X","authenticated-orcid":false,"given":"David Y.","family":"Barefield","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Physiology, Loyola University Chicago, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.86.5.516"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.18.2370"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2022.12.023"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2005.07.018"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.88.3.915"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvr292"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3390\/cells10113220"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.033200"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2020.08.062"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.586041"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa612"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/s0167-5273(03)00107-4"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(96)00439-1"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-021-01982-0"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-021-01078-9"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.130532"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23272-z"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.121264"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.319491"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200305392"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2014.11.018"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00913.2013"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1007\/s12551-014-0151-5"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00946.2020"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00252.2023"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.316366"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.171by.x"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2015.08.016"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.86.11.1114"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.0000021115.24712.99"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.039521"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M308033200"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.meatsci.2004.03.018"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E13-10-0608"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2019.03.006"},{"key":"B36","first-page":"2285","volume":"87","author":"Xue HJ","year":"2007","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.99.6.2297"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M707436200"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000141296.59876.87"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.43.26690"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.045260"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA117.001292"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.103.5.691"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1038\/nsb0402-239"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00029.2002"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.239749"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrep.2021.101162"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.116631"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm_00000448"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2006.08.114"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-019-0726-1"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5922.2010.00245.x"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000261938.28365.11"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.4022\/jafib.1021"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-009-6199-y"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2006.03.005"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00505.2001"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.119.008179"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.011273"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-018-0349-8"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.39702"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90652-1"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(98)00121-1"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000032262.31520.e5"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000055314.10801.4f"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00148.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T14:30:18Z","timestamp":1722868218000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00148.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,1]]},"references-count":65,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,8,1]]}},"alternative-id":["10.1152\/ajpheart.00148.2024"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00148.2024","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.11.05.565691","asserted-by":"object"}]},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,1]]},"assertion":[{"value":"2024-03-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-24","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}