{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:50:07Z","timestamp":1791384607544,"version":"4.3.3"},"reference-count":104,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["AHA23PRE1010870"],"award-info":[{"award-number":["AHA23PRE1010870"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["NIH-F31HL170721"],"award-info":[{"award-number":["NIH-F31HL170721"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["AHA25POST1410066"],"award-info":[{"award-number":["AHA25POST1410066"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["AHA19CDA34630036"],"award-info":[{"award-number":["AHA19CDA34630036"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["NIH-R215R21HL168614-02"],"award-info":[{"award-number":["NIH-R215R21HL168614-02"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["NIH-HL120840"],"award-info":[{"award-number":["NIH-HL120840"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["NIH-HL137112"],"award-info":[{"award-number":["NIH-HL137112"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"<jats:p>These findings demonstrate for the first time that mechanical injury to large artery endothelium induces the expression of gap junction protein Cx43. This upregulation improves the migratory and proliferative capacity of endothelial cells at the wound edge, facilitating timely wound closure. This phenomenon is dependent on appropriate gap junction function and turnover.<\/jats:p>","DOI":"10.1152\/ajpheart.00153.2025","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:21:49Z","timestamp":1759940509000},"page":"H1361-H1377","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Injury-induced connexin 43 expression regulates endothelial wound healing"],"prefix":"10.1152","volume":"329","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9477-8240","authenticated-orcid":false,"given":"Meghan W.","family":"Sedovy","sequence":"first","affiliation":[{"name":"The Fralin Biomedical Research Institute at Virginia Tech Carilion, Center for Vascular and Heart Research","place":["United States"]},{"name":"Virginia Tech","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0909-7948","authenticated-orcid":false,"given":"Mark C.","family":"Renton","sequence":"additional","affiliation":[{"name":"The Fralin Biomedical Research Institute at Virginia Tech Carilion, Center for Vascular and Heart Research","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5713-2941","authenticated-orcid":false,"given":"Kailynn","family":"Roberts","sequence":"additional","affiliation":[{"name":"The Fralin Biomedical Research Institute at Virginia Tech Carilion, Center for Vascular and Heart Research","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyan","family":"Leng","sequence":"additional","affiliation":[{"name":"The Fralin Biomedical Research Institute at Virginia Tech Carilion, Center for Vascular and Heart Research","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1605-7891","authenticated-orcid":false,"given":"Clare L.","family":"Dennison","sequence":"additional","affiliation":[{"name":"The Fralin Biomedical Research Institute at Virginia Tech Carilion, Center for Vascular and Heart Research","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6600-7941","authenticated-orcid":false,"given":"Caroline O.","family":"Toler","sequence":"additional","affiliation":[{"name":"The Fralin Biomedical Research Institute at Virginia Tech Carilion, Center for Vascular and Heart Research","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9103-7448","authenticated-orcid":false,"given":"Melissa R.","family":"Leaf","sequence":"additional","affiliation":[{"name":"The Fralin Biomedical Research Institute at Virginia Tech Carilion, Center for Vascular and Heart Research","place":["United States"]},{"name":"Virginia Tech Carilion School of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1399-2761","authenticated-orcid":false,"given":"Paul D.","family":"Lampe","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela K.","family":"Best","sequence":"additional","affiliation":[{"name":"University of Virginia School of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7692-6294","authenticated-orcid":false,"given":"Brant E.","family":"Isakson","sequence":"additional","affiliation":[{"name":"University of Virginia School of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1920-5033","authenticated-orcid":false,"given":"Scott R.","family":"Johnstone","sequence":"additional","affiliation":[{"name":"The Fralin Biomedical Research Institute at Virginia Tech Carilion, Center for Vascular and Heart Research","place":["United States"]},{"name":"Virginia Tech Carilion School of Medicine","place":["United States"]},{"name":"Virginia Tech Carilion School of Medicine","place":["United States"]},{"id":[{"id":"https:\/\/ror.org\/02smfhw86","id-type":"ROR","asserted-by":"publisher"}],"name":"Virginia Tech","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2023.09.020"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001344"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.064090"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1915922"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3390\/cells11193066"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2014.12.003"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2016.03.007"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-58938-z"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1159\/000535843"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rby006"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(98)00348-9"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2012.64"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.026378"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1080\/17434440.2019.1682996"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11041093"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1186\/s13019-022-01752-7"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8183.2012.00740.x"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2024.116055"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0710516105"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2018.07.011"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.70246"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0288-7"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01742-7"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20235972"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a029199"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00007.2003"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00429"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.83.6.636"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1007\/s004180050432"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1177\/002215549704500406"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq031"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1080\/10641963.2016.1235181"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.19.4179"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1159\/000527469"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.4.1.7"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1681.2002.03699.x"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-7580.1998.19240583.x"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.106.137182"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.627703"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1159\/000430291"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2015.162"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2018.3828"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn112"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23010294"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200707060"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.112.272302"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.149.7.1503"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.2000.2131"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1590\/s0100-879x1998000500001"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M207016200"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000140737.62245.c5"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(96)79328-1"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(96)79686-8"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2014.01.049"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3390\/biom10121596"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2004.09.013"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2017.04.008"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.142497"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200102017"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.090160"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026379"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2010.551"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M404073200"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.22590"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M305072200"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.560"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.197285"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-3281"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M403952200"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.3390\/biom11081192"},{"key":"B71","doi-asserted-by":"publisher","unstructured":"Smyth JW, Guo S, O\u2019Rourke L, Deaver S, Dahlka J, Nurmemmedov E, Sheng Z, Gourdie RG, Lamouille S. Increased interaction between connexin43 and microtubules is critical for glioblastoma stem-like cell maintenance and tumorigenicity (Preprint). bioRxiv 2024. doi:10.1101\/2024.01.26.576347.","DOI":"10.1101\/2024.01.26.576347"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.170472"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1078\/0171-9335-00417"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.17.11.3174"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-08-174508"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.171305298"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.4103\/0975-3583.89804"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2025.108178"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1177\/00236772211042968"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14417"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-023-01249-5"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2017.05.008"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1080\/15419060701755958"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.7.3779"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1016\/s1357-2725(03)00264-4"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.121.316472"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.046308"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2003.09.007"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/18.7.1319"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.6.11.1491"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1016\/s1065-6995(03)00077-5"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E14-06-1105"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E16-07-0496"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcb.2018.07.005"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.121.313788"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvac190"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1159\/000533320"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-0255"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1172\/JCI36940"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12220"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-023-08716-7"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1016\/j.advenzreg.2010.09.005"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2016.06.010"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022806"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00153.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:39:12Z","timestamp":1762868352000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00153.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,1]]},"references-count":104,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,11,1]]}},"alternative-id":["10.1152\/ajpheart.00153.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00153.2025","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.02.24.639946","asserted-by":"object"}]},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,1]]},"assertion":[{"value":"2025-03-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-01","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}