{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T16:11:24Z","timestamp":1778947884476,"version":"3.51.4"},"reference-count":22,"publisher":"American Physiological Society","issue":"6","funder":[{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL151345"],"award-info":[{"award-number":["R01HL151345"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R35HL177035"],"award-info":[{"award-number":["R35HL177035"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:p>Provision of the medium-chain fatty acid octanoate prevented or reversed key metrics of cardiac functional and metabolic deterioration in a large animal model of dilated cardiomyopathy. Our results demonstrate the cardiac benefits of supplementing a medium-chain FA independent of ketosis in a translational model of heart failure. These findings encourage mechanistic and next-stage translational studies into metabolic interventions for the treatment of heart failure.<\/jats:p>","DOI":"10.1152\/ajpheart.00153.2026","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T14:50:48Z","timestamp":1777560648000},"page":"H1785-H1790","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The medium-chain fatty acid octanoate is a beneficial fuel for the failing heart"],"prefix":"10.1152","volume":"330","author":[{"given":"Nikoloz","family":"Gorgodze","sequence":"first","affiliation":[{"name":"Temple University","place":["United States"]},{"name":"Pennsylvania","place":["United States"]},{"name":"The University of Chicago","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1813-6451","authenticated-orcid":false,"given":"Timothy R.","family":"Matsuura","sequence":"additional","affiliation":[{"name":"University of Pennsylvania","place":["United States"]},{"name":"Pennsylvania","place":["United States"]},{"name":"University of Minnesota Medical School","place":["United States"]},{"name":"Minnesota","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noemi","family":"Nisini","sequence":"additional","affiliation":[{"name":"Temple University","place":["United States"]},{"name":"Pennsylvania","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Remus","family":"Berretta","sequence":"additional","affiliation":[{"name":"Temple University","place":["United States"]},{"name":"Pennsylvania","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2722-4835","authenticated-orcid":false,"given":"Alessandra","family":"Recchia","sequence":"additional","affiliation":[{"name":"University of Bari","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alisha","family":"Werlen","sequence":"additional","affiliation":[{"name":"University of Pennsylvania","place":["United States"]},{"name":"Pennsylvania","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"Temple University","place":["United States"]},{"name":"Pennsylvania","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4780-4773","authenticated-orcid":false,"given":"Kirill","family":"Batmanov","sequence":"additional","affiliation":[{"name":"University of Pennsylvania","place":["United States"]},{"name":"Pennsylvania","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Houser","sequence":"additional","affiliation":[{"name":"Temple University","place":["United States"]},{"name":"Pennsylvania","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3811-9491","authenticated-orcid":false,"given":"Daniel P.","family":"Kelly","sequence":"additional","affiliation":[{"name":"University of Pennsylvania","place":["United States"]},{"name":"Pennsylvania","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4189-8465","authenticated-orcid":false,"given":"Fabio A.","family":"Recchia","sequence":"additional","affiliation":[{"name":"Temple University","place":["United States"]},{"name":"Pennsylvania","place":["United States"]},{"name":"Scuola Superiore Sant\u2019Anna","place":["Italy"]},{"name":"Institute of Clinical Physiology of the National Research Council","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.318241"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.124079"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.067971"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00887.2007"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-023-01134-x"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000023531.22727.C1"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.036459"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2023.05.029"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.124.069732"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.117.004417"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.119.006573"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3804"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc8861"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2020.154452"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.052671"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3390\/nu16162707"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(02)01967-8"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.309202"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.117455"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.114.001167"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad100"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16972"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00153.2026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T15:27:28Z","timestamp":1778945248000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00153.2026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,1]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6,1]]}},"alternative-id":["10.1152\/ajpheart.00153.2026"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00153.2026","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,1]]},"assertion":[{"value":"2026-02-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-08","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}