{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T10:06:06Z","timestamp":1792231566541,"version":"4.4.0"},"reference-count":63,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["23TPA1077648"],"award-info":[{"award-number":["23TPA1077648"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["19TPA34910157"],"award-info":[{"award-number":["19TPA34910157"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["HL144943"],"award-info":[{"award-number":["HL144943"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["HL157583"],"award-info":[{"award-number":["HL157583"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:p>Essential hypertension is associated with hyperacetylation of key mitochondrial antioxidant SOD2; however, the pathophysiological role of SOD2 acetylation has not been defined. Our animal study of angiotensin II hypertension model shows that deacetylation mimetic SOD2-K68R mutation prevents pathogenic increase in vascular mitochondrial superoxide, abrogates vascular oxidative stress, preserves endothelial nitric oxide, protects endothelial-dependent vasorelaxation, and attenuates hypertension. These data support the important role of SOD2-K68 acetylation in vascular oxidative stress and the pathogenesis of hypertension.<\/jats:p>","DOI":"10.1152\/ajpheart.00162.2024","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T11:11:26Z","timestamp":1718968286000},"page":"H433-H443","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":25,"title":["Deacetylation mimetic mutation of mitochondrial SOD2 attenuates ANG II-induced hypertension by protecting against oxidative stress and inflammation"],"prefix":"10.1152","volume":"327","author":[{"given":"Anna","family":"Dikalova","sequence":"first","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingfang","family":"Ao","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliya","family":"Tkachuk","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2976-6184","authenticated-orcid":false,"given":"Sergey","family":"Dikalov","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.28.7.1507"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2012.00128"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2011.05.010"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.214601"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4918"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.310933"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00513.2006"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.06.020"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20120118"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.02.018"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5482"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.12.013"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2011.65"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2017.04.022"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-030212-183804"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3390\/ijms16010823"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aac7410"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1172\/JCI14453"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.02.014"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.538934"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.25.5.1111"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00918.2002"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000258594.87211.6b"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2017.7396"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3109\/10715762.2010.540242"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(05)96052-7"},{"key":"B27","volume-title":"Practical Mitochondriology. Pitfalls and Problems in Studies of Mitochondria with Description of Mitochondrial Functions","author":"Panov A","year":"2014"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.315767"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.04.011"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2013.05.008"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.20455\/ros.2016.865"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0601945103"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01271.2010"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.06.033"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00063.2013"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.15236"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1172\/JCI74084"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2019.107418"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.07085"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00595.2018"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-010-9201-5"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00089.2013"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-30018-9_59"},{"key":"B44","first-page":"1","author":"Ostchega Y","year":"2020","journal-title":"NCHS Data Brief"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00969.2004"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-014-0013-7"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/s0891-5849(02)01356-4"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X20915127"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1177\/1947601912474931"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100252"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu059"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.510354"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.84897"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.3109\/08037051.2010.533821"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.2174\/13816128113196660748"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00092.2016"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.315252"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-011-1096-4"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.530"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21062084"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.2174\/138161212799436593"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/876943"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-023-02806-y"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00162.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T12:27:25Z","timestamp":1721996845000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00162.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,1]]},"references-count":63,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,8,1]]}},"alternative-id":["10.1152\/ajpheart.00162.2024"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00162.2024","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,1]]},"assertion":[{"value":"2024-03-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-11","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}