{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T06:26:41Z","timestamp":1781332001224,"version":"3.54.1"},"reference-count":57,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/100000050","name":"Phillip V. & Anna S. Brown Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"name":"LaRue S. Fisher and Walter F. Fisher Memorial Trust"},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["1RO1HL130861"],"award-info":[{"award-number":["1RO1HL130861"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2021,8,1]]},"abstract":"<jats:p> Thioredoxin-interacting protein (Txnip) has been of great interest as a molecular mechanism to mediate diabetic organ damage. Here, we provide novel evidence that a single mutation of Txnip confers a defense mechanism against myocardial oxidative stress in streptoxotocin-induced diabetic mice. The results demonstrate the importance of Txnip as a cysteine-containing redox protein that regulates antioxidant thioredoxin via disulfide bond-switching mechanism, and identify the cysteine in Txnip as a therapeutic target for diabetic cardiomyopathy. <\/jats:p>","DOI":"10.1152\/ajpheart.00174.2021","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T16:05:20Z","timestamp":1622822720000},"page":"H259-H274","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Cardiomyocyte-specific Txnip C247S mutation improves left ventricular functional reserve in streptozotocin-induced diabetic mice"],"prefix":"10.1152","volume":"321","author":[{"given":"Nobuhiro","family":"Mukai","sequence":"first","affiliation":[{"name":"Department of Molecular, Cellular and Biomedical Sciences, City University of New York School of Medicine, City College of New York, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinobu","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Molecular, Cellular and Biomedical Sciences, City University of New York School of Medicine, City College of New York, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Amir","family":"Abdali","sequence":"additional","affiliation":[{"name":"Department of Molecular, Cellular and Biomedical Sciences, City University of New York School of Medicine, City College of New York, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7176-3414","authenticated-orcid":true,"given":"Jun","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"Department of Molecular, Cellular and Biomedical Sciences, City University of New York School of Medicine, City College of New York, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","unstructured":"Services USDoHaH. Estimates of diabetes and its burden in the United States. Centers for Disease Control and Prevention National Diabetes Statistics Report 2020: 1\u201330, 2020. CS314227-A. https:\/\/www.cdc.gov\/diabetes\/data\/statistics-report\/index.html."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-019-0612-8"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.6.1615"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.223545"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c140042"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2006.8.2143"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.012725"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.284612"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.872481"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.2699"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.12.6287"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.31.21645"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M600427200"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M202133200"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-1378"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0712199105"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0901221106"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M400549200"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.2337\/db09-1212"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1127"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800293105"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.08.017"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.01.035"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00051.2016"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.18313"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.018093"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3530"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2021.02.013"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1172\/JCI44927"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1161\/hh1301.092687"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0510444103"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.832915"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.280.5.H1954"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(95)52023-6"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00619.2002"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040158"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2016.03.023"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014050528"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1258\/la.2010.010090"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-010-9131-7"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1161\/hc1202.105290"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00339.2017"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.034421"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1126\/science.291.5504.643"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00297.2003"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-111690"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.4137"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.2007.s110"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.201210772"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1038\/35008121"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00278.2006"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1042\/bj2950287"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.05.041"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.106.160515"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S232221"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0000000000000391"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1159\/000368238"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00174.2021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T11:43:09Z","timestamp":1628595789000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00174.2021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,1]]},"references-count":57,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,8,1]]}},"alternative-id":["10.1152\/ajpheart.00174.2021"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00174.2021","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,1]]},"assertion":[{"value":"2021-03-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}