{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:41:28Z","timestamp":1790664088548,"version":"4.1.0"},"reference-count":58,"publisher":"American Physiological Society","issue":"2","funder":[{"name":"DocPro Ph.D. fellowship","award":["PID33081"],"award-info":[{"award-number":["PID33081"]}]},{"name":"Dehousse Ph.D. fellowship"},{"name":"IOF\/SBO research grant","award":["PID34923"],"award-info":[{"award-number":["PID34923"]}]},{"name":"GOA grant","award":["PID36444"],"award-info":[{"award-number":["PID36444"]}]},{"name":"Senior Clinical Investigator fellowship"},{"name":"Scientific Research Flanders","award":["1842219N"],"award-info":[{"award-number":["1842219N"]}]},{"name":"Scientific Research Flanders","award":["G02019N"],"award-info":[{"award-number":["G02019N"]}]},{"name":"Scientific Research Flanders","award":["G021420N"],"award-info":[{"award-number":["G021420N"]}]},{"name":"ERA.Net RUS Plus","award":["Project Consortium 278"],"award-info":[{"award-number":["Project Consortium 278"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"<jats:p> The role of NRG1\/ERBB signaling in endothelial cells is not completely understood. Our study contributes to the understanding of spatiotemporal heterogeneity of myocardial autocrine and paracrine responses following cardiac injury and shows a role of endothelial autocrine NRG1\/ERBB4 signaling in the modulation of hypertrophic and fibrotic responses during early cardiac remodeling. <\/jats:p>","DOI":"10.1152\/ajpheart.00176.2020","type":"journal-article","created":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T14:53:17Z","timestamp":1593787997000},"page":"H443-H455","source":"Crossref","is-referenced-by-count":48,"title":["The role of endothelial autocrine NRG1\/ERBB4 signaling in cardiac remodeling"],"prefix":"10.1152","volume":"319","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5425-1134","authenticated-orcid":false,"given":"Lindsey","family":"Dugaucquier","sequence":"first","affiliation":[{"name":"Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2275-0983","authenticated-orcid":false,"given":"Eline","family":"Feyen","sequence":"additional","affiliation":[{"name":"Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ligia","family":"Mateiu","sequence":"additional","affiliation":[{"name":"VIB Center for Molecular Neurology, University of Antwerp, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tine Anne Marie","family":"Bruyns","sequence":"additional","affiliation":[{"name":"Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles W.","family":"De Keulenaer","sequence":"additional","affiliation":[{"name":"Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium"},{"name":"Department of Cardiology, Middelheim Hospital, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7796-2222","authenticated-orcid":false,"given":"Vincent F. M.","family":"Segers","sequence":"additional","affiliation":[{"name":"Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium"},{"name":"Department of Cardiology, University Hospital Antwerp, Edegem, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20643"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2011.435"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1418087111"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.04.060"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2011.03.005"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/11.suppl_G.8"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(98)00044-3"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.44"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00630-0"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.205906"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.119.006288"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.735"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1177\/153100350601800123"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.01.035"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2008.02.278"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000773"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2016.10.022"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.12.044"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00048.2005"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1159\/000489622"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvr352"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.991125"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1385\/1-59259-053-5:55"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.68.040104.124629"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2007.03.042"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfq152"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-129072"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.942268"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2006.04.007"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00582"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.690487"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00385.2010"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M600399200"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.30"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt656"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv132"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12390"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2013.01.010"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1007\/s12079-018-0495-x"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20982"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1387\/ijdb.103121eo"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.267286"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.122249299"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu021"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.02.092"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.307778"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2009.06.004"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-005-0514-4"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.4.407"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1999.277.6.H2205"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00382"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.847731"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00206.2017"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00002.2019"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-008-0030-9"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e02-02-0084"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00176.2020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T14:41:12Z","timestamp":1601563272000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00176.2020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,1]]},"references-count":58,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,8,1]]}},"alternative-id":["10.1152\/ajpheart.00176.2020"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00176.2020","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,1]]}}}