{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T15:18:00Z","timestamp":1793114280604,"version":"4.5.0"},"reference-count":52,"publisher":"American Physiological Society","issue":"1","funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["ACD-170302"],"award-info":[{"award-number":["ACD-170302"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["Post-Doctoral Fellowship Award 181747"],"award-info":[{"award-number":["Post-Doctoral Fellowship Award 181747"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002977","name":"Dalhousie University","doi-asserted-by":"crossref","award":["Department of Medicine University Internal Medicine Research Foundation Research Fellowship Award"],"award-info":[{"award-number":["Department of Medicine University Internal Medicine Research Foundation Research Fellowship Award"]}],"id":[{"id":"10.13039\/501100002977","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2024,7,1]]},"abstract":"<jats:p> Longitudinally, our study demonstrates that higher baseline frailty levels are associated with an increased risk of hypertension and heart disease in a large sample of Canadian males and females. Movement partially mediated this relationship, particularly among females. <\/jats:p>","DOI":"10.1152\/ajpheart.00179.2024","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T14:17:13Z","timestamp":1715955433000},"page":"H108-H117","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Relation between frailty and hypertension is partially mediated by physical activity among males and females in the Canadian Longitudinal Study on Aging"],"prefix":"10.1152","volume":"327","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0665-5062","authenticated-orcid":false,"given":"Myles W.","family":"O\u2019Brien","sequence":"first","affiliation":[{"name":"Faculty of Health, School of Physiotherapy, Dalhousie University, Halifax, Nova Scotia, Canada"},{"name":"Faculty of Medicine, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada"},{"name":"Geriatric Medicine Research, Dalhousie University, Halifax, Nova Scotia, Canada"},{"name":"Nova Scotia Health, Halifax, Nova Scotia, Canada"},{"name":"Department of Medicine, Universit\u00e9 de Sherbrooke, Sherbrooke, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Theou","sequence":"additional","affiliation":[{"name":"Faculty of Health, School of Physiotherapy, Dalhousie University, Halifax, Nova Scotia, Canada"},{"name":"Faculty of Medicine, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada"},{"name":"Geriatric Medicine Research, Dalhousie University, Halifax, Nova Scotia, Canada"},{"name":"Nova Scotia Health, Halifax, Nova Scotia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)62167-9"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2012.03.001"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-017-9993-7"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2012.04054.x"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.121.011669"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2017.01.003"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-024406"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2016.12.021"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2019.02.004"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-022-01183-8"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2020-0272"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30370-1"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2013.11.007"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-015-0155-4"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/569194"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000048890.59383.8D"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2022-106503"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1017\/S0714980809990055"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyz173"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afac075"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1100\/tsw.2001.58"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2318-8-24"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00535.2023"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(93)90053-4"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-018-5739-4"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2017-097628"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15112454"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2020.04.014"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1037\/\/0022-3514.51.6.1173"},{"key":"B30","volume-title":"Discovering Statistics Using IBM SPSS Statistics","author":"Field A","year":"2017","edition":"5"},{"key":"B31","volume-title":"Introduction to Mediation, Moderation, and Conditional Process Analysis: A Regression-Based Approach","author":"Hayes A","year":"2018","edition":"2"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2017.1125"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2023.01.004"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.51507"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-021-01097-9"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1111\/sms.12581"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2021-0246"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2018.00135"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2014.10.001"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-015-0600-y"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1249\/JES.0000000000000275"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-02100-x"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.pec.2021.09.019"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.968792"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.121.011714"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afaa144"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1007\/s11332-022-00898-0"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0594.2008.00463.x"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2018-0033"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1017\/S071498081500029X"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.34178"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.121.007917"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00179.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T00:53:33Z","timestamp":1718412813000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00179.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,1]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,7,1]]}},"alternative-id":["10.1152\/ajpheart.00179.2024"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00179.2024","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,1]]},"assertion":[{"value":"2024-03-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-14","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}