{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:21:08Z","timestamp":1773418868214,"version":"3.50.1"},"reference-count":29,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2002,8,1]]},"abstract":"<jats:p> We investigated the contributions of forebrain, brain stem, and spinal neural circuits to interleukin (IL)-1\u03b2-induced sympathetic nerve discharge (SND) responses in \u03b1-chloralose-anesthetized rats. Lumbar and splenic SND responses were determined in spinal cord-transected (first cervical vertebra, C1), midbrain-transected (superior colliculus), and sham-transected rats before and for 60 min after intravenous IL-1\u03b2 (285 ng\/kg). The observations made were the following: 1) lumbar and splenic SND were significantly increased after IL-1\u03b2 in sham C1-transected rats but were unchanged after IL-1\u03b2 in C1-transected rats; 2) intrathecal administration of dl-homocysteic acid (10 ng) increased SND in C1-transected rats; 3) lumbar and splenic SND were significantly increased after IL-1\u03b2 in sham- but not midbrain-transected rats; and 4) midbrain transection did not alter the pattern of lumbar and splenic SND, demonstrating the integrity of brain stem sympathetic neural circuits after decerebration. These results demonstrate that an intact forebrain is required for mediating lumbar and splenic sympathoexcitatory responses to intravenous IL-1\u03b2, thereby providing new information about the organization of neural circuits responsible for mediating sympathetic-immune interactions. <\/jats:p>","DOI":"10.1152\/ajpheart.00181.2002","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:03:14Z","timestamp":1425412994000},"page":"H501-H505","source":"Crossref","is-referenced-by-count":6,"title":["Sympathoexcitation to intravenous interleukin-1\u03b2 is  dependent on forebrain neural circuits"],"prefix":"10.1152","volume":"283","author":[{"given":"Michael J.","family":"Kenney","sequence":"first","affiliation":[{"name":"Department of Anatomy and Physiology and Department of Clinical Sciences, Kansas State University, Manhattan, Kansas 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