{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T23:03:15Z","timestamp":1769727795105,"version":"3.49.0"},"reference-count":230,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/501100000184","name":"Trent University","doi-asserted-by":"publisher","award":["53-52714"],"award-info":[{"award-number":["53-52714"]}],"id":[{"id":"10.13039\/501100000184","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2022,10,1]]},"abstract":"<jats:p> Cardiac cachexia is a catabolic muscle-wasting syndrome observed in approximately 1 in 10 patients with heart failure. Increased skeletal muscle atrophy leads to frailty and limits mobility, which impacts quality of life, exacerbates clinical care, and is associated with higher rates of mortality. Heart failure is known to exhibit a wide range of prevalence and severity when examined across individuals of different ages and with comorbidities related to diabetes, renal failure, and pulmonary dysfunction. It is also recognized that men and women exhibit striking differences in the pathophysiology of heart failure, as well as skeletal muscle homeostasis. Given that both skeletal muscle and heart failure physiology are in part sex-dependent, the diagnosis and treatment of cachexia in patients with heart failure may depend on a comprehensive examination of how these organs interact. In this review, we explore the potential for sex-specific differences in cardiac cachexia. We summarize advantages and disadvantages of clinical methods used to measure muscle mass and function and provide alternative measurements that should be considered in preclinical studies. In addition, we summarize sex-dependent effects on muscle wasting in preclinical models of heart failure, disuse, and cancer. Lastly, we discuss the endocrine function of the heart and outline unanswered questions that could directly impact patient care. <\/jats:p>","DOI":"10.1152\/ajpheart.00187.2022","type":"journal-article","created":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T16:30:49Z","timestamp":1660321849000},"page":"H609-H627","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["The importance of biological sex in cardiac cachexia"],"prefix":"10.1152","volume":"323","author":[{"given":"Ethan R.","family":"Holder","sequence":"first","affiliation":[{"name":"Trent University, Peterborough, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8145-4682","authenticated-orcid":false,"given":"Faisal J.","family":"Alibhai","sequence":"additional","affiliation":[{"name":"University Health Network, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha L.","family":"Caudle","sequence":"additional","affiliation":[{"name":"Trent University, Peterborough, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"McDermott","sequence":"additional","affiliation":[{"name":"York University, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5780-6238","authenticated-orcid":false,"given":"Stephanie W.","family":"Tobin","sequence":"additional","affiliation":[{"name":"Trent University, Peterborough, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CLNU.2008.06.013"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/S13539-010-0002-6"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/JCSM.12603"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-019-1073-3"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.63.6043"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1002\/CNCR.28218"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1002\/JCSM.12161"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/JCSM.12167"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1097\/SPC.0000000000000456"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/J.NUT.2011.12.002"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1093\/GERONA\/56.3.M146"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-011-0025-7"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1093\/OXFORDJOURNALS.AJE.A009520"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1007\/S12603-018-1138-X"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S273967"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.15252\/EMBR.201847258"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1093\/EURHEARTJ\/EHZ835"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1093\/GERONA\/GLT136"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20123-1"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1152\/PHYSIOL.00024.2014"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/253067"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00861"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1093\/AGEING\/AFY169"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1002\/JCSM.12390"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1126\/science.1065874"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1186\/S12576-020-00768-9\/FIGURES\/2"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2009.10.008"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3390\/CELLS9091970"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1210\/ENDO.142.4.8082"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.305393"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1242\/JCS.001222"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7670"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/J.CYTOGFR.2021.04.001"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1152\/AJPHEART.00200.2011"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4652(199907)180:1<1::AID-JCP1>3.0.CO;2-V"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.05.010"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(98)00205-6"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.2174\/187152210793663810"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-018-0888-y"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1210\/EN.2006-1653"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1210\/ER.2007-0001"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1152\/AJPCELL.00333.2021"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-70178-3_9"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1074\/JBC.M910345199"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.06.025"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIOCEL.2013.05.035"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1186\/2042-6410-3-7"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/S0047-6374(98)00130-4"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1093\/GERONA\/GLS068"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1007\/S13539-012-0060-Z"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.035550"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1136\/BMJ.G5992"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1007\/S10557-015-6599-0"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.968792"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.319900"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1136\/BMJ.L1631"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1054\/JCAF.2002.32195"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00411-7"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1152\/PHYSREV.00021.2015"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2009.01.060"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.2353\/AJPATH.2007.060505"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1161\/RES.123.SUPPL_1.453"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1113\/EP089163"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0232399"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1177\/0960327113477874"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1152\/AJPREGU.00638.2009"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.14814\/PHY2.14608"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/J.BBADIS.2014.12.015"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1002\/JCSM.12693"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1007\/s12576-018-0640-6"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.14814\/PHY2.15042"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1152\/AJPREGU.00825.2009"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1210\/EN.2012-1353"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1007\/S00109-008-0385-4"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1152\/AJPHEART.00723.2004"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00157.2022"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart006442021"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS23010174"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00071.2022"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/J.CARDIORES.2006.08.018"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.017091"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(02)00535-1"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.3945\/AJCN.2010.28608C"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1007\/S11914-020-00628-W"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1007\/S11897-017-0361-9"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1002\/JCSM.12488"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1007\/S11897-015-0257-5"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1093\/EURHEARTJ\/EHV598"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1093\/eurjcn\/zvac054"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1186\/S13293-019-0257-3"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1016\/J.IJCARD.2016.05.071"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1002\/JCSM.12678"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIOCEL.2013.05.016"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1016\/J.AJPATH.2020.04.006"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1038\/S41586-019-1100-Z"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200018010-00016"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1002\/EJHF.239"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00517.2002"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1096\/FASEBJ.31.1_SUPPLEMENT.691.4"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00389.2018"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1002\/EHF2.12915"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1113\/JP280899"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00212.2011"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1186\/S13395-020-00229-2"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1016\/J.JACBTS.2017.07.013"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1152\/AJPHEART.00282.2015"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1113\/EXPPHYSIOL.2014.084095"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1152\/JAPPLPHYSIOL.00898.2018"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1002\/JCSM.12233"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1002\/JCSM.12448"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.915215"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1002\/EHF2.13142"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.116.003027"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1002\/JCSM.12612"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1152\/AJPHEART.00270.2022"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1016\/J.ARR.2010.11.002"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1002\/ART.11025"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.3177\/JNSV.53.37"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114419"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1002\/IJC.20270"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1182\/BLOOD-2017-07-746446"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.15252\/EMBR.202153746"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1053\/EUHJ.1998.1446"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1161\/HC4201.097836"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.2.526"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1073\/PNAS.97.8.4279"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1084\/JEM.20111020"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1152\/JAPPLPHYSIOL.00869.2005"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.3389\/FENDO.2019.00720"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1210\/EN.2013-1004"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0B013E31817E7420"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1007\/S12020-012-9836-3"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1016\/J.IJCARD.2008.11.146"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02059-4"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1093\/GERONA\/51A.3.M95"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1152\/AJPHEART.1995.268.1.H391"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.155895"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118698"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1007\/S40520-019-01292-6"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1536\/IHJ.18-131"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1161\/HC3601.095575"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1002\/JCSM.12254"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1038\/NRENDO.2013.67"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1172\/JCI22324"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1016\/J.IJCARD.2016.06.231"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1186\/S13395-015-0047-5"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.882068"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1152\/AJPENDO.00107.2003"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-11-0455"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.2174\/1573403X12666160111125304"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1016\/J.EXGER.2021.111228"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.3390\/CELLS11071073"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1161\/RES.129.SUPPL_1.P330"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(15)60990-1"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1007\/S00395-003-0411-1"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1152\/JAPPLPHYSIOL.90884.2008"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1093\/GERONA\/GLU145"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1038\/S41598-017-07236-2"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1016\/J.OMTN.2020.12.015"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2013.00394"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.3390\/nu12020297"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1016\/J.CCA.2014.06.022"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfp088"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000149746.62908.BB"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1177\/0148607114566854"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1016\/J.BONE.2019.03.033"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1210\/JC.2011-2387"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1007\/S00520-013-1832-5"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1002\/JCSM.12295"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.597675"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1007\/S10741-016-9593-0"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.308030"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.3390\/cells9081894"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1016\/J.YJMCC.2020.12.001"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199007263230405"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1016\/J.EBIOM.2017.01.040"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-2364com"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1016\/J.JMB.2008.08.087"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.1038\/NRI.2016.90"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.1186\/S13395-019-0205-2"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1152\/AJPREGU.00689.2009"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1126\/SCIIMMUNOL.AAP8855"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-021-00086-8"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1016\/J.BBRC.2013.10.042"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.1113\/JP276432"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13312"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115668"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.1126\/SCIENCE.1140485"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.1113\/EP089962"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.2337\/DC14-0669"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.1002\/JCSM.12631"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.11909\/J.ISSN.1671-5411.2020.01.008"},{"key":"B194","doi-asserted-by":"publisher","DOI":"10.1186\/S12872-020-01514-0"},{"key":"B195","doi-asserted-by":"publisher","DOI":"10.1038\/NM1677"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0001385"},{"key":"B197","doi-asserted-by":"publisher","DOI":"10.1016\/J.IJCARD.2017.03.153"},{"key":"B198","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4392"},{"key":"B199","doi-asserted-by":"publisher","DOI":"10.1016\/J.TEM.2020.10.004"},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.1016\/J.CELREP.2018.01.044"},{"key":"B201","doi-asserted-by":"publisher","DOI":"10.3390\/CELLS10112990"},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.1136\/THORAXJNL-2017-211440"},{"key":"B203","doi-asserted-by":"publisher","DOI":"10.1002\/JCSM.12096"},{"key":"B204","doi-asserted-by":"publisher","DOI":"10.15252\/EMMM.201707604"},{"key":"B205","doi-asserted-by":"publisher","DOI":"10.3892\/br.2016.725"},{"key":"B206","doi-asserted-by":"publisher","DOI":"10.1016\/J.BCP.2022.114954"},{"key":"B207","doi-asserted-by":"publisher","DOI":"10.1073\/PNAS.1402714111"},{"key":"B208","doi-asserted-by":"publisher","DOI":"10.1016\/J.OMTN.2021.04.015"},{"key":"B209","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00726-x"},{"key":"B210","doi-asserted-by":"publisher","DOI":"10.1002\/JCSM.12851"},{"key":"B211","doi-asserted-by":"publisher","DOI":"10.1152\/AJPCELL.00223.2020"},{"key":"B212","doi-asserted-by":"publisher","DOI":"10.1042\/BST20180213"},{"key":"B213","doi-asserted-by":"publisher","DOI":"10.1002\/JCSM.12844"},{"key":"B214","doi-asserted-by":"publisher","DOI":"10.1007\/S11357-021-00322-4"},{"key":"B215","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-69297-0"},{"key":"B216","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq013"},{"key":"B217","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq167"},{"key":"B218","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08895-7"},{"key":"B219","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.015687"},{"key":"B220","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029173"},{"key":"B221","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.90562.2008"},{"key":"B222","doi-asserted-by":"publisher","DOI":"10.1172\/JCI36154"},{"key":"B223","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-18003-8"},{"key":"B224","doi-asserted-by":"publisher","DOI":"10.1016\/J.CELL.2012.03.029"},{"key":"B225","doi-asserted-by":"publisher","DOI":"10.15252\/EMMM.201404218"},{"key":"B226","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.29896"},{"key":"B227","doi-asserted-by":"publisher","DOI":"10.1038\/MT.2012.35"},{"key":"B228","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15201"},{"key":"B229","doi-asserted-by":"publisher","DOI":"10.1210\/EN.2013-1763"},{"key":"B230","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-03887-3"},{"key":"B231","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.028595"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00187.2022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T13:45:47Z","timestamp":1663163147000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00187.2022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,1]]},"references-count":230,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,10,1]]}},"alternative-id":["10.1152\/ajpheart.00187.2022"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00187.2022","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,1]]},"assertion":[{"value":"2022-04-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-19","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}