{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T07:13:18Z","timestamp":1794035598638,"version":"4.8.0"},"reference-count":31,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["HL144528"],"award-info":[{"award-number":["HL144528"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","award":["202241049"],"award-info":[{"award-number":["202241049"]}],"id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2023,10,1]]},"abstract":"<jats:p> Vascular endothelial cells represent the first line of exposure to bacterial endotoxins. Here, we propose a novel therapeutic strategy using liposomes to deliver preassembled glycocalyx to vascular endothelial cell surface and consequently restore endothelial glycocalyx (EG). We tested liposomal nanocarriers of preassembled glycocalyx (LNPG) in vivo and ex vivo to establish for the first time their expeditious therapeutic efficacy in improving survival of lipopolysaccharides (LPS)-treated mice, as achieved by the restoration of EG and recovery of endothelial function. <\/jats:p>","DOI":"10.1152\/ajpheart.00196.2023","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T15:09:02Z","timestamp":1690556942000},"page":"H645-H655","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Liposomal nanocarriers of preassembled glycocalyx expeditiously restore endothelial glycocalyx in endotoxemia"],"prefix":"10.1152","volume":"325","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0007-8847","authenticated-orcid":false,"given":"Shinya","family":"Ishiko","sequence":"first","affiliation":[{"name":"Department of Medicine, New York Medical College, Valhalla, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghada","family":"Ben Rahoma","sequence":"additional","affiliation":[{"name":"Department of Physiology, New York Medical College, Valhalla, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4674-0325","authenticated-orcid":false,"given":"Sharath","family":"Kandhi","sequence":"additional","affiliation":[{"name":"Department of Physiology, New York Medical College, Valhalla, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3207-8502","authenticated-orcid":false,"given":"An","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Physiology, New York Medical College, Valhalla, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4845-2180","authenticated-orcid":false,"given":"Dong","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Physiology, New York Medical College, Valhalla, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-007-0212-8"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq137"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2006.01620.x"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfx076"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/wsbm.1211"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00288.2015"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00832.2003"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aer269"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-06-1887"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2019.06.017"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2015.10.001"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2018.03.003"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0250327"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-018-2292-6"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1159\/000522050"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1999.277.2.H508"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-010-1910-x"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2843"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00923.2010"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(03)72004-7"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-021-03520-w"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20184411"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1021\/bi050620i"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.55.02.06.db05-1103"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2019.111596"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00104.2018"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-96445-4_1"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000101744.47866.D5"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2022.12.009"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2015.06.006"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2017.07.014"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00196.2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T15:53:09Z","timestamp":1692978789000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00196.2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,1]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,10,1]]}},"alternative-id":["10.1152\/ajpheart.00196.2023"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00196.2023","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,1]]},"assertion":[{"value":"2023-04-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-26","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}