{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:06:07Z","timestamp":1791288367127,"version":"4.3.0"},"reference-count":41,"publisher":"American Physiological Society","issue":"2","funder":[{"name":"national program on key basic research project","award":["2914CB542400"],"award-info":[{"award-number":["2914CB542400"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"<jats:p>Progesterone directly upregulated endothelial nitric oxide synthase (eNOS) expression in human endothelial cells. Progesterone augmented eNOS promoter activity through a progesterone receptor A- and specificity protein-1-dependent manner. Antagonism of the progesterone receptor reduced eNOS expression and impaired vasodilation in rats.<\/jats:p>","DOI":"10.1152\/ajpheart.00206.2020","type":"journal-article","created":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T10:53:17Z","timestamp":1593773597000},"page":"H341-H348","source":"Crossref","is-referenced-by-count":38,"title":["Progesterone promotes endothelial nitric oxide synthase expression through enhancing nuclear progesterone receptor-SP-1 formation"],"prefix":"10.1152","volume":"319","author":[{"given":"Yuehua","family":"You","sequence":"first","affiliation":[{"name":"Division of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanying","family":"Tan","sequence":"additional","affiliation":[{"name":"Division of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzheng","family":"Guo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghao","family":"Luo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei-fei","family":"Shang","sequence":"additional","affiliation":[{"name":"Institute of Life Science, Chongqing Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Xia","sequence":"additional","affiliation":[{"name":"Division of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"},{"name":"Institute of Life Science, Chongqing Medical University, Chongqing, China"},{"name":"Division of Cardiovascular Medicine, Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suxin","family":"Luo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"},{"name":"Institute of Life Science, Chongqing Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s000180050358"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.37.1.142"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1126\/science.2781282"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13148"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2005.03068.x"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-13-0263"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-009-0017-3"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1177\/1933719116671002"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.85.5.1927"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2017.05.006"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1332667100"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.2.786"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328347da54"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.1.49"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.9.2795"},{"key":"B16","first-page":"87","volume":"89","author":"Harrison DG","year":"1994","journal-title":"Basic Res Cardiol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000126372.14332.70"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(92)90524-8"},{"key":"B19","first-page":"573","volume":"54","author":"Kannel WB","year":"1978","journal-title":"Bull N Y Acad Med"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.05.019"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.6.2226"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2010.04.014"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1021\/mp0500418"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80243-3"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1369\/jhc.5A6759.2006"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-200401000-00002"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1515\/hmbci-2015-0070"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199312303292706"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.87.5.406"},{"key":"B30","first-page":"370","volume":"80","author":"Omar HA","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/327524a0"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00527.2014"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1997.272.1.H386"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.3.321"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.290.6461.13"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1126\/science.3201230"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2003.08.006"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2013.01.003"},{"key":"B39","first-page":"459","volume":"14","author":"Truss M","year":"1993","journal-title":"Endocr Rev"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.17.4.667"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb04062.x"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00206.2020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T18:53:01Z","timestamp":1595357581000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00206.2020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,1]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,8,1]]}},"alternative-id":["10.1152\/ajpheart.00206.2020"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00206.2020","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,1]]}}}