{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:04:22Z","timestamp":1790643862941,"version":"4.1.0"},"reference-count":40,"publisher":"American Physiological Society","issue":"3","funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["HL109478"],"award-info":[{"award-number":["HL109478"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"HHS National Institutes of Health","award":["HL118491"],"award-info":[{"award-number":["HL118491"]}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:p>Hyperoxia impairs NO-mediated cGMP generation by augmenting cytosolic ROS. Cinaciguat rescued cGMP responsiveness in hyperoxic cells, hence oxidative damage to sGC is responsible. Increases in ROS in hyperoxic embryonic mouse lungs recapitulated responses previously recorded in adult mice. Hence, unlike premature infants, late gestational lung antioxidant maturation in the mouse is robust. Defects in lung alveolarization induced by hyperoxia were not rescued by cinaciguat or riociguat; hence, impaired cGMP signaling does not impair lung alveolarization.<\/jats:p>","DOI":"10.1152\/ajpheart.00207.2026","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T16:24:25Z","timestamp":1784823865000},"page":"H1000-H1011","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Role of ROS, soluble guanylate cyclase and cGMP in mouse lung development during hyperoxia"],"prefix":"10.1152","volume":"331","author":[{"given":"My Linh","family":"Nguyen","sequence":"first","affiliation":[{"name":"Ann & Robert H. Lurie Children\u2019s Hospital of Chicago","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joann M.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Ann & Robert H. Lurie Children\u2019s Hospital of Chicago","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. Joseph","family":"Dudley","sequence":"additional","affiliation":[{"name":"Ann & Robert H. Lurie Children\u2019s Hospital of Chicago","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6179-4209","authenticated-orcid":false,"given":"Gregory B.","family":"Waypa","sequence":"additional","affiliation":[{"name":"Ann & Robert H. Lurie Children\u2019s Hospital of Chicago","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9591-2034","authenticated-orcid":false,"given":"Paul T.","family":"Schumacker","sequence":"additional","affiliation":[{"name":"Ann & Robert H. Lurie Children\u2019s Hospital of Chicago","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196702162760701"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1089\/ped.2013.0323"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.67.040403.102229"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3345\/kjp.2010.53.6.688"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0183-2023"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.semperi.2023.151817"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2017.3171"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000509.pub5"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-018-0258-9"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.047753"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-024-03562-0"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00176.2014"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.4184"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.206334"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20130740"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-008-9538-4"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201302-0302OC"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2020-0023OC"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00228.2014"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.01113"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M312847200"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M312846200"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.6b00582"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00319.2018"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0180957"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2013-0118OC"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1021\/bi200794c"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201100809"},{"key":"B29","first-page":"131","volume":"124","author":"Amy RW","year":"1977","journal-title":"J Anat"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1136\/thx.37.8.564"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.152.2.7633720"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.4.9810071"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.161463"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10111672"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.03.003"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2862"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2023.104624"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1021\/cb600492a"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0199927"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00401.2012"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00207.2026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:14:38Z","timestamp":1788452078000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00207.2026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9,1]]}},"alternative-id":["10.1152\/ajpheart.00207.2026"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00207.2026","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,1]]},"assertion":[{"value":"2026-03-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-13","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}