{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:22:50Z","timestamp":1790882570409,"version":"4.1.0"},"reference-count":37,"publisher":"American Physiological Society","issue":"1","funder":[{"name":"Corgenix Medical, Inc."},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["17GRNT3360007"],"award-info":[{"award-number":["17GRNT3360007"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006955","name":"HHS | NIH | Office of Extramural Research, National Institutes of Health","doi-asserted-by":"publisher","award":["5TL1TR001454-03"],"award-info":[{"award-number":["5TL1TR001454-03"]}],"id":[{"id":"10.13039\/100006955","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2022,7,1]]},"abstract":"<jats:p> Nonplatelet thromboxane generation in heart failure is independently associated with risk of death, transplant, or need for mechanical support. Measurement of urine thromboxane metabolites using a clinically available assay may be a useful surrogate for invasive measurement of cardiovascular hemodynamics and performance that could provide prognostic information and facilitate tailoring of therapy in patients with heart failure. Inhibiting nonplatelet thromboxane generation or its biological effects is a potential strategy for improving cardiovascular performance and outcomes in heart failure. <\/jats:p>","DOI":"10.1152\/ajpheart.00212.2022","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T17:52:20Z","timestamp":1655488340000},"page":"H248-H255","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Nonplatelet thromboxane generation is associated with impaired cardiovascular performance and mortality in heart failure"],"prefix":"10.1152","volume":"323","author":[{"given":"Essa","family":"Hariri","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts"},{"name":"Department of Medicine, Cleveland Clinic Foundation, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Kakouros","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7050-5042","authenticated-orcid":true,"given":"David A.","family":"Bunsick","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1115-0349","authenticated-orcid":true,"given":"Stuart D.","family":"Russell","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James O.","family":"Mudd","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Laws","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhailia W.","family":"Lake","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8607-4569","authenticated-orcid":true,"given":"Jeffrey J.","family":"Rade","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts"},{"name":"Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.768283"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000013777.21160.07"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.007486"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-021219"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.04.034"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.003702"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.27437"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2017.11.003"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2008.01.001"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.596627"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002615"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.10.047"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2016.10.022"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.03820.x"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704416"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/s0891-5849(99)00264-6"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2012.03.025"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1080\/00401706.1974.10489231"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.117.004436"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.112.967828"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi555"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12026"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1086\/676020"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1992.217"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(97)70253-9"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(86)90905-8"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.312144"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000153349.77489.CF"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfp053"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.09.028"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.08.650"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1186\/2050-6511-15-73"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00930.2005"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1086\/686140"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-020-1113-2"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.011902"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.86.2.513"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00212.2022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T14:58:31Z","timestamp":1657205911000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00212.2022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,1]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,7,1]]}},"alternative-id":["10.1152\/ajpheart.00212.2022"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00212.2022","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,1]]},"assertion":[{"value":"2022-05-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-08","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}