{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:56:24Z","timestamp":1790704584130,"version":"4.1.0"},"reference-count":191,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2012,8,1]]},"abstract":"<jats:p>Although pharmacological and interventional advances have reduced the morbidity and mortality of ischemic heart disease, there is an ongoing need for novel therapeutic strategies that prevent or reverse progressive ventricular remodeling following myocardial infarction, the process that forms the substrate for ventricular failure. The development of cell-based therapy as a strategy to repair or regenerate injured tissue offers extraordinary promise for a powerful anti-remodeling therapy. In this regard, the field of cell therapy has made major advancements in the past decade. Accumulating data from preclinical studies have provided novel insights into stem cell engraftment, differentiation, and interactions with host cellular elements, as well as the effectiveness of various methods of cell delivery and accuracy of diverse imaging modalities to assess therapeutic efficacy. These findings have in turn guided rationally designed translational clinical investigations. Collectively, there is a growing understanding of the parameters that underlie successful cell-based approaches for improving heart structure and function in ischemic and other cardiomyopathies.<\/jats:p>","DOI":"10.1152\/ajpheart.00221.2012","type":"journal-article","created":{"date-parts":[[2012,5,26]],"date-time":"2012-05-26T05:10:58Z","timestamp":1338009058000},"page":"H256-H270","source":"Crossref","is-referenced-by-count":72,"title":["Cell-based therapy for prevention and reversal of myocardial remodeling"],"prefix":"10.1152","volume":"303","author":[{"given":"Vasileios","family":"Karantalis","sequence":"first","affiliation":[{"name":"Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, Florida; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne","family":"Balkan","sequence":"additional","affiliation":[{"name":"Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, Florida; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivonne H.","family":"Schulman","sequence":"additional","affiliation":[{"name":"Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, Florida; and"},{"name":"Nephrology-Hypertension Section, Miami Veterans Affairs Healthcare System, Miami, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos E.","family":"Hatzistergos","sequence":"additional","affiliation":[{"name":"Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, Florida; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua M.","family":"Hare","sequence":"additional","affiliation":[{"name":"Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, Florida; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn097"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/bit.22006"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504388102"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.01.068"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5302.964"},{"key":"B6","author":"Assmus B","year":"2011","journal-title":"Eur Heart J"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2010.173"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/nature02460"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000084828.50310.6A"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/ncpcardio0738"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0706760104"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00687-1"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200106073442303"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.04.060"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)00005-5"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2009.01.017"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.20284"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61590-0"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-437X(00)00215-X"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1186\/scrt29"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100090504"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0732"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-006-0023-x"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-02-075481"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.236521"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-010-9125-6"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2009.02.003"},{"key":"B28","first-page":"1443","volume":"117","author":"Chen SL","year":"2004","journal-title":"Chin Med J (Engl)"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2011.10.002"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1089\/107632704323061762"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.04.040"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M201462200"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02932"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.04.056"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0602877103"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000153847.47301.80"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2005.03.016"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2008.12.137"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.10.3838"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2012.0084"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-7580.2002.00030.x"},{"key":"B42","author":"Dulce RA","year":"2011","journal-title":"Eur Heart J"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.4161\/cc.4.10.2081"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.22-5-849"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2003.09.011"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.884403"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.09.125"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00255-7"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.04.055"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.668707"},{"key":"B51","doi-asserted-by":"crossref","first-page":"3106","DOI":"10.1182\/blood.V95.10.3106","volume":"95","author":"Gehling UM","year":"2000","journal-title":"Blood"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.141614"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2010.10.054"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.176826"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1006\/excr.2000.5145"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2010.156"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1007\/s11373-007-9207-x"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.11.057"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1686"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.06.055"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.222703"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(02)03477-4"},{"key":"B63","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/jor.20956","volume":"28","author":"Ho JH","year":"2010","journal-title":"J Orthop Res"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.07.002"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1172\/JCI12150"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-02-0586"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1002\/art.10696"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1038\/nature08899"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000151843.79801.60"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1161\/hc3501.093817"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2011.05.015"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.185298"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2010.0456"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1038\/nature08804"},{"key":"B75","first-page":"I96","volume":"112","author":"Kim BO","year":"2005","journal-title":"Circulation"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000118601.37875.AC"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1002\/art.24330"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00546.x"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1007\/s11373-004-8183-7"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1038\/86498"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2004.05.021"},{"key":"B82","doi-asserted-by":"crossref","first-page":"I173","DOI":"10.1161\/CIRCULATIONAHA.104.526178","volume":"112","author":"Kofidis T","year":"2005","journal-title":"Circulation"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040440"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2005-0008"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1038\/nm1619"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951110001435"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1327"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)62041-X"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1038\/nature03215"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1411406"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-011-0327-y"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.06.010"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00013.2005"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.243154"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1002\/stem.532"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.11.029"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2006-0771"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2006.07.002"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2009.11.008"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.150755"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2006.01.061"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1172\/JCI5298"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60195-0"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2011.175"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1038\/nm912"},{"key":"B106","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1242\/jcs.115.10.2075","volume":"115","author":"Marchetti S","year":"2002","journal-title":"J Cell Sci"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2003.09.028"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1210\/endo.138.10.5425"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2010007500093"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1038\/ncpcardio0770"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67380-1"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000147315.71699.51"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2002.92.1.288"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2007.01.005"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1126\/science.1110542"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1038\/nm1671"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.02.002"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1038\/nature02446"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.240218"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3049"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1038\/nm1040"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2132126100"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1038\/35070587"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.181177898"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2184.2008.00552.x"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvm025"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00705.2008"},{"key":"B128","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1182\/blood.V95.3.952.003k27_952_958","volume":"95","author":"Peichev M","year":"2000","journal-title":"Blood"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1038\/ncpcardio0447"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.418"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.176131"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5411.143"},{"key":"B133","first-page":"3","volume":"251","author":"Pittenger MF","year":"2000","journal-title":"Curr Top Microbiol Immunol"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.09.003"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0903201106"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0416"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(02)00739-3"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2007.11.014"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1042\/BST0371218"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31823ac046"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1186\/1476-9255-2-8"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2004.02.058"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-02-002246"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jep191"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00762.2007"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp265"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00058.2004"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.249052"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(02)03517-8"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.09.050"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1111\/j.1752-8062.2011.00283.x"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000151812.86142.45"},{"key":"B153","first-page":"214","volume":"31","author":"Silva GV","year":"2004","journal-title":"Tex Heart Inst J"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.03.043"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-007-9077-x"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.06.017"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000142866.50300.EB"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.09.003"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1415.048"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000034046.87607.1C"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2011-0014"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000087430.17543.b8"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2008.06.017"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00397-8"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.080409"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1161\/hc0102.101442"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn218"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1670"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2009.06.009"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000045055.63901.A9"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1172\/JCI39896"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0500169102"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2012.02.018"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2010.03.001"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.885236"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2005.02.001"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1038\/nature05944"},{"key":"B178","doi-asserted-by":"crossref","first-page":"A13079","DOI":"10.1161\/CIRCULATIONAHA.110.008318","volume":"124","author":"Williams A","year":"2011","journal-title":"Circulation"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.242610"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.1177\/153537020422900706"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.109.189662"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030329"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.30667"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.909093"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.659730"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2007.0289"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2006.12.9"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2010.06.007"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.1016\/j.trre.2008.05.005"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-005-0553-4"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1089\/107632701300062859"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00221.2012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T22:15:08Z","timestamp":1743200108000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpheart.00221.2012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,1]]},"references-count":191,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,8,1]]}},"alternative-id":["10.1152\/ajpheart.00221.2012"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00221.2012","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,1]]}}}