{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:03:05Z","timestamp":1790643785286,"version":"4.1.0"},"reference-count":63,"publisher":"American Physiological Society","issue":"4","funder":[{"name":"Fraternal Order of Eagles Diabetes Research Center"},{"DOI":"10.13039\/100006108","name":"HHS | NIH | National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR002537"],"award-info":[{"award-number":["UL1TR002537"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL169201"],"award-info":[{"award-number":["HL169201"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:p>Women who have gestational diabetes during pregnancy are at a greater risk for cardiovascular disease and type 2 diabetes in the decade following pregnancy. The mechanisms mediating this increased risk are unclear. Herein, we demonstrate that insulin-dependent microvascular responses are reduced in women who had gestational diabetes, despite the remission of glucose intolerance. This reduced microvascular sensitivity to insulin may contribute to increased cardiovascular disease and type 2 diabetes risk in these women.<\/jats:p>","DOI":"10.1152\/ajpheart.00223.2024","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T11:16:28Z","timestamp":1721992588000},"page":"H793-H803","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["Impaired microvascular insulin-dependent dilation in women with a history of gestational diabetes"],"prefix":"10.1152","volume":"327","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1418-1813","authenticated-orcid":false,"given":"Kelsey S.","family":"Schwartz","sequence":"first","affiliation":[{"name":"Department of Health and Human Physiology, The University of Iowa, Iowa City, Iowa, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola V.","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Department of Health and Human Physiology, The University of Iowa, Iowa City, Iowa, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace S.","family":"Maurer","sequence":"additional","affiliation":[{"name":"Department of Health and Human Physiology, The University of Iowa, Iowa City, Iowa, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3740-8742","authenticated-orcid":false,"given":"Elizabeth M.","family":"Wetzel","sequence":"additional","affiliation":[{"name":"Department of Health and Human Physiology, The University of Iowa, Iowa City, Iowa, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Carver College of Medicine, Iowa City, Iowa, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1975-8650","authenticated-orcid":false,"given":"Diana I.","family":"Jalal","sequence":"additional","affiliation":[{"name":"The Iowa City Veterans Affairs Healthcare System, Iowa City, Iowa, United States"},{"name":"Department of Internal Medicine, Carver College of Medicine, Iowa City, Iowa, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3941-3879","authenticated-orcid":false,"given":"Anna E.","family":"Stanhewicz","sequence":"additional","affiliation":[{"name":"Department of Health and Human Physiology, The University of Iowa, Iowa City, Iowa, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002501"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2070926"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.044784"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2013-303945"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-019-4840-2"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60731-5"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000129501.88485.1f"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjab024"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.563213"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.300291"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.169722"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2013.06.017"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.01.018"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.03.013"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00189.2022"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.09386"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00249.2022"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3791\/51478"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.127514"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1159\/000231715"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016050521"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-7-123"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2010.117"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2010.10"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00858.2007"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2012.10.010"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1042\/CS20070431"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.304591"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-199-43333"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1210\/endo.130.1.1727716"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1549-8719.2012.00174.x"},{"key":"B32","first-page":"347","volume":"7","author":"Tymms DJ","year":"1988","journal-title":"Int J Microcirc Clin Exp"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.984047"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.21.12.2111"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00115.2011"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2011.01829.x"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1159\/000065543"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2015.1099719"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2020.104104"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.9.1856"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1111\/micc.12114"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000129772.26647.6F"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.5.1515"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.657486"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/s1089-8603(02)00111-8"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.309678"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703393"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2012.03.005"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4004(03)00183-8"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-019-2258-y"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2003.12.005"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2003.00869.x"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.3390\/biology10010018"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2018.07.015"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-8902.2004.00364.x"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00254.2003"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00233.2020"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328333d1fc"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.2147\/vhrm.s3920"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2010.03.048"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-014-0272-9"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.0000051384.43104.fc"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13517"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00223.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T09:11:46Z","timestamp":1726045906000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00223.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,1]]},"references-count":63,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,10,1]]}},"alternative-id":["10.1152\/ajpheart.00223.2024"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00223.2024","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,1]]},"assertion":[{"value":"2024-04-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-03","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}