{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T06:25:13Z","timestamp":1789626313709,"version":"build-2803163510"},"reference-count":40,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2002,9,1]]},"abstract":"<jats:p>Hearts from diabetic db\/ db mice, a model of Type 2 diabetes, exhibit left ventricular failure and altered metabolism of exogenous substrates. Peroxisome proliferator-activated receptor-\u03b1 (PPAR-\u03b1) ligands reduce plasma lipid and glucose concentrations and improve insulin sensitivity in db\/ db mice. Consequently, the effect of 4- to 5-wk treatment of db\/ db mice with a novel PPAR-\u03b1 ligand (BM 17.0744; 25\u201338 mg \u00b7 kg<jats:sup>\u22121<\/jats:sup>\u00b7 day<jats:sup>\u22121<\/jats:sup>), commencing at 8 wk of age, on ex vivo cardiac function and metabolism was determined. Elevated plasma concentrations of glucose, fatty acids, and triacylglycerol (34.0 \u00b1 3.6, 2.0 \u00b1 0.4, and 0.9 \u00b1 0.1 mM, respectively) were reduced to normal after treatment with BM 17.0744 (10.8 \u00b1 0.6, 1.1 \u00b1 0.1, and 0.6 \u00b1 0.1 mM). Plasma insulin was also reduced significantly in treated compared with untreated db\/ db mice. Chronic treatment of db\/ db mice with the PPAR-\u03b1 agonist resulted in a 50% reduction in rates of fatty acid oxidation, with a concomitant increase in glycolysis (1.7-fold) and glucose oxidation (2.3- fold). Correction of the diabetes-induced abnormalities in systemic and cardiac metabolism after BM 17.0744 treatment did not, however, improve left ventricular contractile function.<\/jats:p>","DOI":"10.1152\/ajpheart.00226.2001","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:03:45Z","timestamp":1425413025000},"page":"H949-H957","source":"Crossref","is-referenced-by-count":112,"title":["Cardiac function and metabolism in Type 2 diabetic mice after treatment with BM 17.0744, a novel PPAR-\u03b1 activator"],"prefix":"10.1152","volume":"283","author":[{"given":"Ellen","family":"Aasum","sequence":"first","affiliation":[{"name":"Department of Medical Physiology, University of Troms\u00f8, N-9037 Troms\u00f8, Norway;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darrell D.","family":"Belke","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, University of Calgary, Calgary, Alberta, Canada T2N 4N1; 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