{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T18:07:13Z","timestamp":1789409233493,"version":"build-2803163510"},"reference-count":85,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-180303"],"award-info":[{"award-number":["PJT-180303"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","award":["0051-2019"],"award-info":[{"award-number":["0051-2019"]}],"id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","award":["00067-2020"],"award-info":[{"award-number":["00067-2020"]}],"id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["RO1-DK121848"],"award-info":[{"award-number":["RO1-DK121848"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:p>Acute kidney injury (AKI) is common in patients with open-heart surgery, but early diagnostics and therapies are limited. This study identifies a proinflammatory pathway activated during cardiopulmonary bypass. UDP-sugars are ligands of the P2Y14 receptor that appear during surgery in the urine of patients with AKI, predicting its onset. Patients with elevated UDP-sugars exhibited higher urinary inflammatory markers. Thus, the UDP-sugar\/P2Y14 axis may serve as an early predictor and therapeutic target for cardiac surgery-related AKI.<\/jats:p>","DOI":"10.1152\/ajpheart.00233.2026","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:01:49Z","timestamp":1787097709000},"page":"H1105-H1121","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Urinary UDP-sugars provide actionable prediction of acute kidney injury in cardiac surgery patients"],"prefix":"10.1152","volume":"331","author":[{"given":"Christine","family":"L\u00e9gar\u00e9","sequence":"first","affiliation":[{"name":"CHU de Qu\u00e9bec-Universit\u00e9 Laval Research Center","place":["Canada"]},{"name":"Universit\u00e9 Laval","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Caron","sequence":"additional","affiliation":[{"name":"CHU de Qu\u00e9bec-Universit\u00e9 Laval Research Center","place":["Canada"]},{"name":"Universit\u00e9 Laval","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9521-480X","authenticated-orcid":false,"given":"Mohammad M.","family":"Al-Bataineh","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5766-2933","authenticated-orcid":false,"given":"Aisha","family":"Ford","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Emlet","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Deslauriers","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Laval","place":["Canada"]},{"name":"CHU de Qu\u00e9bec-Universit\u00e9 Laval Research Center","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5011-7798","authenticated-orcid":false,"given":"Dennis","family":"Brown","sequence":"additional","affiliation":[{"name":"Harvard Medical School and Massachusetts General Hospital","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1113-1212","authenticated-orcid":false,"given":"Chantal","family":"Guillemette","sequence":"additional","affiliation":[{"name":"CHU de Qu\u00e9bec-Universit\u00e9 Laval Research Center","place":["Canada"]},{"name":"Universit\u00e9 Laval","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siamak","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Laval","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6380-8689","authenticated-orcid":false,"given":"Sylvie","family":"Breton","sequence":"additional","affiliation":[{"name":"CHU de Qu\u00e9bec-Universit\u00e9 Laval Research Center","place":["Canada"]},{"name":"Universit\u00e9 Laval","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.06040613"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004090740"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-015-3934-7"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfag019"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00710113"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.16541221"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-025-01030-4"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfae231"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-017-3695-3"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318168c590"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-019-01119-8"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013070780"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60647-9"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aes357"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2019.04.004"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00552.2015"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/s0003-4975(99)00566-4"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1002\/j.2040-4603.2012.tb00431.x"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(03)01346-8"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2025.11.009"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2025.10.013"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1002\/j.2040-4603.2013.tb00511.x"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-018-0015-5"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00106.2024"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001461"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2009.01.267"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-016-1352-z"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015030261"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2005.05.069"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00266.2024"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivu014"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2017.119"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000504"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.648"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1369\/0022155419852932"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0200056"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.125503"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2018.10.007"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1111\/nep.12941"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2015.01.005"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.022"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1152\/function.087.2025"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1172\/JCI134791"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1124\/mol.115.098756"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-1217-1_1"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1124\/mol.63.5.1190"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R114.619304"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31008"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00038.2018"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900001"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0121419"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.15.10767"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1124\/mol.64.4.785"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M806759200"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00138.2012"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1007\/s11302-016-9524-5"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2022.463296"},{"key":"B58","author":"Belardin LB","year":"2021","journal-title":"Mol Hum Reprod"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1159\/000519265"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1159\/000488303"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1007\/BF01463929"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00128.2001"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1177\/1740774513497540"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.374"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02430315"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.202"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009060636"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2014.05.008"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1159\/000484960"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5001527"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00127.2021"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1097\/01.ccx.0000145095.90327.f2"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1053\/j.jrn.2026.04.010"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.0000001192"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0000001268"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1097\/01.asn.0000130340.93930.dd"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2021.04.055"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12832"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03754.x"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01349-1"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.0000000745"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2025.2545983"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.4c00489"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-021-10129-7"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2021060734"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00233.2026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T17:38:29Z","timestamp":1789407509000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00233.2026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":85,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,10,1]]}},"alternative-id":["10.1152\/ajpheart.00233.2026"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00233.2026","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,1]]},"assertion":[{"value":"2026-03-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-15","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}