{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T12:22:47Z","timestamp":1792498967270,"version":"4.5.0"},"reference-count":45,"publisher":"American Physiological Society","issue":"3","funder":[{"DOI":"10.13039\/501100000024","name":"Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de recherche en sant\u00e9 du Canada)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2017,3,1]]},"abstract":"<jats:p> Both estrogen and hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) have been shown to inhibit the development of atherosclerosis. We previously reported that cystathionine \u03b3-lyase knockout (CSE-KO) male mice develop atherosclerosis earlier than male wild-type (WT) mice. The present study investigated the interaction of CSE\/H<jats:sub>2<\/jats:sub>S pathway and estrogen on the development of atherosclerosis in female mice. Plasma estrogen levels were significantly lower in female CSE-KO mice than in female WT mice. NaHS treatment had no effect on plasma estrogen levels in both WT and CSE-KO female mice. After CSE-KO and WT female mice were fed with atherogenic diet for 12 wk, plasma lipid levels were significantly increased and triglyceride levels decreased compared with those of control diet-fed mice. Atherogenic diet induced more atherosclerotic lesion, oxidative stress, intracellular adhesion molecule-1 (ICAM-1), and NF-\u03baB in CSE-KO mice than in WT mice. Estrogen treatment of atherogenic diet-fed WT mice attenuated hypercholesterolemia, oxidative stress, ICAM-1 expression, and NF-\u03baB in WT mice but not in atherogenic diet-fed CSE-KO mice. Furthermore, H<jats:sub>2<\/jats:sub>S production in both the liver and vascular tissues was enhanced by estrogen in WT mice but not in CSE-KO mice. It is concluded that the antiatherosclerotic effect of estrogen is mediated by CSE-generated H<jats:sub>2<\/jats:sub>S. This study provides new insights into the interaction of H<jats:sub>2<\/jats:sub>S and estrogen signaling pathways on the regulation of cardiovascular functions. <\/jats:p><jats:p> NEW &amp; NOTEWORTHY Female cystathionine \u03b3-lyase (CSE)-knockout mice have significantly lower plasma estrogen levels and more severe early atherosclerotic lesion than female wild-type mice. H<jats:sub>2<\/jats:sub>S production in liver and vascular tissues is enhanced by estrogen via its stimulatory effect on CSE activity. The antiatherosclerotic effect of estrogen is mediated by CSE-generated H<jats:sub>2<\/jats:sub>S. <\/jats:p>","DOI":"10.1152\/ajpheart.00245.2016","type":"journal-article","created":{"date-parts":[[2016,12,16]],"date-time":"2016-12-16T20:56:36Z","timestamp":1481921796000},"page":"H406-H414","source":"Crossref","is-referenced-by-count":47,"title":["The interaction of estrogen and CSE\/H<sub>2<\/sub>S pathway in the development of atherosclerosis"],"prefix":"10.1152","volume":"312","author":[{"given":"Hongzhu","family":"Li","sequence":"first","affiliation":[{"name":"Department of Biology, Lakehead University, Thunder Bay, Ontario, Canada;"},{"name":"Department of Pathophysiology, Harbin Medical University, Harbin, People\u2019s Republic of China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarathi","family":"Mani","sequence":"additional","affiliation":[{"name":"Department of Biology, Lakehead University, Thunder Bay, Ontario, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyun","family":"Wu","sequence":"additional","affiliation":[{"name":"Cardiovascular and Metabolic Research Unit, Laurentian University, Sudbury, Ontario, Canada;"},{"name":"Health Sciences North Research Institute, Sudbury, Ontario, Canada; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Fu","sequence":"additional","affiliation":[{"name":"Cardiovascular and Metabolic Research Unit, Laurentian University, Sudbury, Ontario, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Shuang","sequence":"additional","affiliation":[{"name":"Cardiovascular and Metabolic Research Unit, Laurentian University, Sudbury, Ontario, Canada;"},{"name":"Department of Biology, Laurentian University, Sudbury, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changqing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Harbin Medical University, Harbin, People\u2019s Republic of China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biology, Lakehead University, Thunder Bay, Ontario, Canada;"},{"name":"Cardiovascular and Metabolic Research Unit, Laurentian University, Sudbury, Ontario, Canada;"},{"name":"Department of Biology, Laurentian University, Sudbury, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1500113"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(03)00097-2"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.19.10022"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.87.10.840"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.01.001"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.49.5_Suppl_4.S15"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(01)00462-X"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/878052"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.11.048"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2012.08.036"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041614"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2007.00177.x"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3181\/0811-RM-338"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1586\/ecp.10.130"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2014.02.006"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.002208"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/s11434-014-0722-7"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5324"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.01.038"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000026393.47805.21"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/nature12932"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901143400207"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.190041"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.01.132"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.02.024"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(01)02087-8"},{"key":"B27","first-page":"441","volume":"46","author":"Tyagi N","year":"2009","journal-title":"Indian J Biochem Biophys"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-009-9103-z"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1089\/152308603768295249"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2014.03.003"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.180190"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00017.2011"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0211hyp"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-3623(02)00129-5"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3181\/0811-RM-332"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.182279"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.04.028"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp420"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1126\/science.1162667"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.21.6008"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1258\/ebm.2010.010308"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1096\/fj.07-105353"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gas044"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0b013e3182874732"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2004.05.013"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00245.2016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T01:46:30Z","timestamp":1567993590000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpheart.00245.2016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,1]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3,1]]}},"alternative-id":["10.1152\/ajpheart.00245.2016"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00245.2016","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,1]]}}}