{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T14:12:30Z","timestamp":1779804750598,"version":"3.53.1"},"reference-count":41,"publisher":"American Physiological Society","issue":"6","funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E-26\/211.526\/2021"],"award-info":[{"award-number":["E-26\/211.526\/2021"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E-26\/204.249\/2025 (313975)"],"award-info":[{"award-number":["E-26\/204.249\/2025 (313975)"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["(CNPq"],"award-info":[{"award-number":["(CNPq"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["# 304697\/2020-6)"],"award-info":[{"award-number":["# 304697\/2020-6)"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R00HL159241"],"award-info":[{"award-number":["R00HL159241"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020326","name":"Instituto D'Or de Pesquisa e Ensino","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020326","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:p>Long-term breast cancer (BC) survivors previously treated with doxorubicin- and trastuzumab-based chemotherapy show reduced muscle metaboreflex activation, which partly explains attenuated pressor and sympathetic neural responses to exercise in this population. Importantly, these findings shed light on the blunted exercise-induced blood pressure increase observed in long-term BC survivors.<\/jats:p>","DOI":"10.1152\/ajpheart.00252.2026","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T15:01:37Z","timestamp":1778079697000},"page":"H1951-H1959","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Attenuated pressor and sympathetic neural responses to exercise in long-term breast cancer survivors: role of the muscle metaboreflex"],"prefix":"10.1152","volume":"330","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3312-489X","authenticated-orcid":false,"given":"Jo\u00e3o E.","family":"Izaias","sequence":"first","affiliation":[{"name":"D'Or Institute for Research and Education (IDOR)","place":["Brazil"]},{"name":"D'Or Institute for Research and Education (IDOR)","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4235-3691","authenticated-orcid":false,"given":"Bruna E.","family":"Ono","sequence":"additional","affiliation":[{"name":"D'Or Institute for Research and Education (IDOR)","place":["Brazil"]},{"name":"D'Or Institute for Research and Education (IDOR)","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9795-3745","authenticated-orcid":false,"given":"Artur O.","family":"Sales","sequence":"additional","affiliation":[{"name":"D'Or Institute for Research and Education (IDOR)","place":["Brazil"]},{"name":"D'Or Institute for Research and Education (IDOR)","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6075-2448","authenticated-orcid":false,"given":"Thais S.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"D'Or Institute for Research and Education (IDOR)","place":["Brazil"]},{"name":"D'Or Institute for Research and Education (IDOR)","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielly M. P. S.","family":"Silva","sequence":"additional","affiliation":[{"name":"D'Or Institute for Research and Education (IDOR)","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6550-1498","authenticated-orcid":false,"given":"Roberta F.","family":"Lima","sequence":"additional","affiliation":[{"name":"D'Or Institute for Research and Education (IDOR)","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila S.","family":"Nunes","sequence":"additional","affiliation":[{"name":"D'Or Institute for Research and Education (IDOR)","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matheus A.","family":"Bittencourt","sequence":"additional","affiliation":[{"name":"D'Or Institute for Research and Education (IDOR)","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0295-2902","authenticated-orcid":false,"given":"Priscilla S.","family":"Pentagna","sequence":"additional","affiliation":[{"name":"D'Or Institute for Research and Education (IDOR)","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera M. C.","family":"Salemi","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3220-019X","authenticated-orcid":false,"given":"Fernanda M.","family":"Consolim-Colombo","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2097-3662","authenticated-orcid":false,"given":"Maria C. C.","family":"Irigoyen","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda G.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4652-1226","authenticated-orcid":false,"given":"Carlos E.","family":"Negr\u00e3o","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6080-7429","authenticated-orcid":false,"given":"Laura","family":"Testa","sequence":"additional","affiliation":[{"name":"D'Or Institute for Research and Education (IDOR)","place":["Brazil"]},{"name":"Universidade de S\u00e3o Paulo","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3640-9049","authenticated-orcid":false,"given":"Katia","family":"De Angelis","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo (UNIFESP)","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9ia M.","family":"Porcari","sequence":"additional","affiliation":[{"name":"University of Campinas (UNICAMP)","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4741-7343","authenticated-orcid":false,"given":"Helena N. M.","family":"Rocha","sequence":"additional","affiliation":[{"name":"State University of Rio de Janeiro","place":["Brazil"]},{"name":"Fluminense Federal University","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7078-1880","authenticated-orcid":false,"given":"Gabriel F.","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Fluminense Federal University","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1990-9834","authenticated-orcid":false,"given":"Natalia G.","family":"Rocha","sequence":"additional","affiliation":[{"name":"Fluminense Federal University","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3830-2886","authenticated-orcid":false,"given":"Antonio C. L.","family":"da N\u00f3brega","sequence":"additional","affiliation":[{"name":"Fluminense Federal University","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8744-5349","authenticated-orcid":false,"given":"Daniel H.","family":"Craighead","sequence":"additional","affiliation":[{"name":"University of Minnesota","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3878-3533","authenticated-orcid":false,"given":"Zachary S.","family":"Clayton","sequence":"additional","affiliation":[{"name":"University of Colorado Boulder","place":["United States"]},{"name":"University of Colorado Anschutz","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8587-7319","authenticated-orcid":false,"given":"Renata J.","family":"Moll-Bernardes","sequence":"additional","affiliation":[{"name":"D'Or Institute for Research and Education (IDOR)","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4407-9043","authenticated-orcid":false,"given":"Allan R. K.","family":"Sales","sequence":"additional","affiliation":[{"name":"D'Or Institute for Research and Education (IDOR)","place":["Brazil"]},{"name":"D'Or Institute for Research and Education (IDOR)","place":["Brazil"]},{"name":"Universidade de S\u00e3o Paulo","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz766"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac244"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21871"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c140022"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00077.2015"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.125.048047"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00476.2023"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00756.2018"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.004784"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccao.2024.08.005"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1097\/HCR.0000000000000718"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3389\/FPHYS.2013.00224"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000001242"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00308.2018"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2006.02.001"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.281.2.H469"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.280.3.H969"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.124.011962"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2025.103251"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.064274"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.112.202598"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2017.11.017"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-53491-0.00028-6"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1046\/j.0001-6772.2003.01211.x"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2009.050815"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2010.02133.x"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-022-00872-3"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00080.2021"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2015.08.004"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000432"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000679"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2025.103057"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.213769"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000162473.10951.0A"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2019-0777"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00045.2023"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.122.062814"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2021-0399"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2005.030262"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00841.2017"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00360.2016"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00252.2026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T13:41:57Z","timestamp":1779802917000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00252.2026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,1]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6,1]]}},"alternative-id":["10.1152\/ajpheart.00252.2026"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00252.2026","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,1]]},"assertion":[{"value":"2026-03-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-06","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}