{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:24:12Z","timestamp":1793381052183,"version":"4.5.0"},"reference-count":52,"publisher":"American Physiological Society","issue":"1","funder":[{"DOI":"10.13039\/100010557","name":"USC | Office of the Vice President for Research, University of South Carolina","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010557","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL133662"],"award-info":[{"award-number":["R01HL133662"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"HHS | NIH | National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["R03EB019663"],"award-info":[{"award-number":["R03EB019663"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2022,1,1]]},"abstract":"<jats:p> Male Fbn-1<jats:sup>C1041G\/+<\/jats:sup> mice show more severe thoracic aortic changes compared with females, especially at 12 mo of age. Up to 6 mo of age, Sca-1<jats:sup>+<\/jats:sup> smooth muscle progenitor cells are more abundant in the adventitia of both male and female Fbn-1 Het mice compared with wild types (WTs). Male and female Het mice show similar patterns of expression of Sca-1<jats:sup>+<\/jats:sup> cells at early ages. <\/jats:p>","DOI":"10.1152\/ajpheart.00255.2021","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T17:32:42Z","timestamp":1635528762000},"page":"H44-H56","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":37,"title":["Age and sex dependency of thoracic aortopathy in a mouse model of Marfan syndrome"],"prefix":"10.1152","volume":"322","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3600-9907","authenticated-orcid":true,"given":"Nazli","family":"Gharraee","sequence":"first","affiliation":[{"name":"Biomedical Engineering Program, University of South Carolina, Columbia, South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujian","family":"Sun","sequence":"additional","affiliation":[{"name":"Physical Therapy Program, Brenau University, Gainesville, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Swisher","sequence":"additional","affiliation":[{"name":"Internal Medicine, Tulane University School of Medicine, New Orleans, Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8409-5216","authenticated-orcid":true,"given":"Susan M.","family":"Lessner","sequence":"additional","affiliation":[{"name":"Biomedical Engineering Program, University of South Carolina, Columbia, South Carolina"},{"name":"Department of Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq224"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2005.09.018"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genom.8.080706.092303"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/S0945-053X(00)00099-8"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2017.07.004"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2008.160515"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.116.001647"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGEN.117.002058"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1126\/science.1124287"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.mgene.2013.10.008"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1544479"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.304412"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1867"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.305368"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.223800"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1172\/JCI19628"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.06123"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.157776"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.medengphy.2008.03.002"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2016.1036"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00933"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2015.11.059"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1172\/jci20641"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00420.2020"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00041.2003"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0910312107"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000155243.70456.F4"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1998.tb03714.x"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2018.06.034"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.06.094"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.489"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq258"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.08.025"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.117.309599"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.116.303229"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.88.1.37"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2009.07.075"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivv074"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.231548"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3651"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2015.05.006"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.300902"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.120.314670"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1038\/S41467-020-15647-5"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1002\/EJI.201847583"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.309322"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00217.2016"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1253\/circrep.cr-18-0012"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/J.JVS.2012.10.007"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2014.07.003"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-64071-8"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1126\/science.1253026"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00255.2021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T18:45:32Z","timestamp":1639075532000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00255.2021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,1]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1,1]]}},"alternative-id":["10.1152\/ajpheart.00255.2021"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00255.2021","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,1]]},"assertion":[{"value":"2021-05-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}