{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T23:28:34Z","timestamp":1768692514735,"version":"3.49.0"},"reference-count":40,"publisher":"American Physiological Society","issue":"11","funder":[{"DOI":"10.13039\/501100004327","name":"SingHealth Foundation","doi-asserted-by":"publisher","award":["SHF\/FG453P\/2011"],"award-info":[{"award-number":["SHF\/FG453P\/2011"]}],"id":[{"id":"10.13039\/501100004327","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Goh Cardiovascular Research Grant","award":["Duke-NUSGCR\/2013\/0009"],"award-info":[{"award-number":["Duke-NUSGCR\/2013\/0009"]}]},{"DOI":"10.13039\/501100001349","name":"MOH | National Medical Research Council (NMRC)","doi-asserted-by":"publisher","award":["NMRC\/EDG\/1037\/2011"],"award-info":[{"award-number":["NMRC\/EDG\/1037\/2011"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Singapore-China Joint Research Programme","award":["14\/1\/32\/24\/002"],"award-info":[{"award-number":["14\/1\/32\/24\/002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2015,12,1]]},"abstract":"<jats:p>The assessment of atrioventricular junction (AVJ) deformation plays an important role in evaluating left ventricular systolic and diastolic function in clinical practice. This study aims to demonstrate the effectiveness and consistency of cardiovascular magnetic resonance (CMR) for quantitative assessment of AVJ velocity compared with tissue Doppler echocardiography (TDE). A group of 145 human subjects comprising 21 healthy volunteers, 8 patients with heart failure, 17 patients with hypertrophic cardiomyopathy, 52 patients with myocardial infarction, and 47 patients with repaired Tetralogy of Fallot were prospectively enrolled and underwent TDE and CMR scan. Six AVJ points were tracked with three CMR views. The peak systolic velocity (Sm1), diastolic velocity during early diastolic filling (Em), and late diastolic velocity during atrial contraction (Am) were extracted and analyzed. All CMR-derived septal and lateral AVJ velocities correlated well with TDE measurements (Sm1: r = 0.736; Em: r = 0.835; Am: r = 0.701; Em\/Am: r = 0.691; all p &lt; 0.001) and demonstrated excellent reproducibility [intrastudy: r = 0.921\u20130.991, intraclass correlation coefficient (ICC): 0.918\u20130.991; interstudy: r = 0.900\u20130.970, ICC: 0.887\u20130.957; all p &lt; 0.001]. The evaluation of three-dimensional AVJ motion incorporating measurements from all views better differentiated normal and diseased states [area under the curve (AUC) = 0.918] and provided further insights into mechanical dyssynchrony diagnosis in HF patients (AUC = 0.987). These findings suggest that the CMR-based method is feasible, accurate, and consistent in quantifying the AVJ deformation, and subsequently in diagnosing systolic and diastolic cardiac dysfunction.<\/jats:p>","DOI":"10.1152\/ajpheart.00284.2015","type":"journal-article","created":{"date-parts":[[2015,9,26]],"date-time":"2015-09-26T01:09:05Z","timestamp":1443229745000},"page":"H1923-H1935","source":"Crossref","is-referenced-by-count":27,"title":["Automated quantitative assessment of cardiovascular magnetic resonance-derived atrioventricular junction velocities"],"prefix":"10.1152","volume":"309","author":[{"given":"Shuang","family":"Leng","sequence":"first","affiliation":[{"name":"National Heart Centre Singapore, Singapore;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Dan","family":"Zhao","sequence":"additional","affiliation":[{"name":"National Heart Centre Singapore, Singapore;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei-Qiong","family":"Huang","sequence":"additional","affiliation":[{"name":"National Heart Centre Singapore, Singapore;"},{"name":"Duke-NUS Graduate Medical School Singapore, Singapore; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Ing","family":"Wong","sequence":"additional","affiliation":[{"name":"National Heart Centre Singapore, Singapore;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo-Yang","family":"Su","sequence":"additional","affiliation":[{"name":"National Heart Centre Singapore, Singapore;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John Carson","family":"Allen","sequence":"additional","affiliation":[{"name":"Duke-NUS Graduate Medical School Singapore, Singapore; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghassan S.","family":"Kassab","sequence":"additional","affiliation":[{"name":"California Medical Innovations Institute, San Diego, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ru-San","family":"Tan","sequence":"additional","affiliation":[{"name":"National Heart Centre Singapore, Singapore;"},{"name":"Duke-NUS Graduate Medical School Singapore, Singapore; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Zhong","sequence":"additional","affiliation":[{"name":"National Heart Centre Singapore, Singapore;"},{"name":"Duke-NUS Graduate Medical School Singapore, Singapore; and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euje.2005.12.012"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2006.11.024"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(03)00634-5"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01148.2006"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.742486"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jep164"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.109.926022"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1186\/1476-7120-10-46"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1385\/1-59259-898-6:405"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)00990-9"},{"key":"B11","volume-title":"Digital Image Processing","author":"Gonzalez RC","year":"2006"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)02381-0"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2004.09.007"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.579268"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/9781444306309"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jet004"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn596"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-14-43"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(03)00279-7"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jer154"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.020628"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-16-35"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-15-S1-E53"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-16-S1-P20"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01231.2009"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)88335-0"},{"key":"B27","unstructured":"Stewart J. 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