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Multisite interstitial stimulation should therefore give rise to interstitial potential differences recorded centrally that depend on intracellular and interstitial microimpedances, allowing independent measurement. Simulations of multisite stimulation with fine (25 \u03bcm) and wide (400 \u03bcm) spacing in one-dimensional models that included Luo-Rudy dynamic membrane equations were performed. Constant interstitial and intracellular microimpedances were prescribed for initial analyses. Discrete myoplasmic and gap-junctional components were prescribed intracellularly in later simulations. With constant microimpedances, multisite stimulation using 29 total electrode combinations allowed interstitial and intracellular microimpedance measurements at errors of 0.30% and 0.34%, respectively, with errors of 0.05% and 0.40% achieved using 6 combinations and 10 total electrodes. With discrete myoplasmic and junctional components, comparable accuracy was maintained following adjustments to the junctions to reflect uncoupling. This allowed uncoupling to be quantified as relative increases in total junctional resistance. Our findings suggest development of microfabricated devices to implement the procedure would facilitate routine measurement as a component of cardiac electrophysiological study. <\/jats:p>","DOI":"10.1152\/ajpheart.00289.2004","type":"journal-article","created":{"date-parts":[[2004,7,30]],"date-time":"2004-07-30T00:15:05Z","timestamp":1091146505000},"page":"H2402-H2411","source":"Crossref","is-referenced-by-count":11,"title":["Feasibility of cardiac microimpedance measurement using multisite interstitial stimulation"],"prefix":"10.1152","volume":"287","author":[{"given":"Andrew E.","family":"Pollard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William M.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger C.","family":"Barr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.84.3.1307"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1986.251.1.H210"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(01)00197-3"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1995.tb00381.x"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.66.6.1461"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1161\/hh2101.098612"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1114\/1.100"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1976.sp011283"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.80.6.765"},{"key":"R10","unstructured":"Garbow BS, Hillstrom KE, and More JJ. 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