{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:21:04Z","timestamp":1773706864375,"version":"3.50.1"},"reference-count":48,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p> Hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) is a biologically active endogenous gasotransmitter formed in penile tissue that has been shown to relax isolated cavernosal smooth muscle. In the present study, erectile responses to the H<jats:sub>2<\/jats:sub>S donors sodium sulfide (Na<jats:sub>2<\/jats:sub>S) and sodium hydrosulfide (NaHS) were investigated in the anesthetized rat. Intracavernosal injections of Na<jats:sub>2<\/jats:sub>S in doses of 0.03\u20131 mg\/kg increased intracavernosal pressure and transiently decreased mean arterial pressure in a dose-dependent manner. Blood pressure responses to Na<jats:sub>2<\/jats:sub>S were rapid in onset and short in duration. Responses to Na<jats:sub>2<\/jats:sub>S and NaHS were similar at doses up to 0.3 mg\/kg, after which a plateau in the erectile response to NaHS was reached. Increases in intracavernosal pressure in response to Na<jats:sub>2<\/jats:sub>S were attenuated by tetraethylammonium (K<jats:sup>+<\/jats:sup> channel inhibitor) and iberiotoxin (large-conductance Ca<jats:sup>2+<\/jats:sup>-activated K<jats:sup>+<\/jats:sup> channel inhibitor), whereas glybenclamide [ATP-sensitive K<jats:sup>+<\/jats:sup> (K<jats:sub>ATP<\/jats:sub>) channel inhibitor] and inhibitors of nitric oxide (NO) synthase, cyclooxygenase, and cytochrome P-450 epoxygenase had no effect. These data indicate that erectile responses to Na<jats:sub>2<\/jats:sub>S are mediated by a tetraethylammonium- and iberiotoxin-sensitive mechanism and that K<jats:sub>ATP<\/jats:sub> channels, NO, or arachidonic acid metabolites are not involved. Na<jats:sub>2<\/jats:sub>S did not alter erectile responses to sodium nitroprusside (NO donor) or cavernosal nerve stimulation, indicating that neither NO nor cGMP metabolism are altered. Thus, Na<jats:sub>2<\/jats:sub>S has erectile activity mediated by large-conductance Ca<jats:sup>2+<\/jats:sup>-activated K<jats:sup>+<\/jats:sup> channels. It is suggested that strategies that increase H<jats:sub>2<\/jats:sub>S formation in penile tissue may be useful in the treatment of erectile dysfunction when NO bioavailability, K<jats:sub>ATP<\/jats:sub> channel function, or poor responses to PGE<jats:sub>1<\/jats:sub> are present. <\/jats:p>","DOI":"10.1152\/ajpheart.00293.2015","type":"journal-article","created":{"date-parts":[[2015,6,27]],"date-time":"2015-06-27T12:03:51Z","timestamp":1435406631000},"page":"H835-H843","source":"Crossref","is-referenced-by-count":23,"title":["Analysis of erectile responses to H<sub>2<\/sub>S donors in the anesthetized rat"],"prefix":"10.1152","volume":"309","author":[{"given":"Ryan C.","family":"Jupiter","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward A.","family":"Pankey","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishwaradh V. 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