{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:00:15Z","timestamp":1790791215603,"version":"4.1.0"},"reference-count":39,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/100000027","name":"HHS | NIH | National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["RO1AA024082"],"award-info":[{"award-number":["RO1AA024082"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"HHS | NIH | National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["RO1AA031225"],"award-info":[{"award-number":["RO1AA031225"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:p>We identify a previously unrecognized biphasic effect of alcohol on endothelial phenotypic plasticity. Low-to-moderate-dose alcohol suppresses endothelial-to-mesenchymal transition (EndMT), whereas high-level (binge) exposure promotes this proatherogenic process. Given the central role of EndMT in vascular remodeling and atherosclerosis, these findings provide a mechanistic framework linking alcohol consumption and cardiovascular disease risk \u2013 potentially explaining both the protective effect at low-to-moderate levels, and the detrimental impact of heavy alcohol use.<\/jats:p>","DOI":"10.1152\/ajpheart.00310.2026","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T17:42:18Z","timestamp":1789494138000},"page":"H1363-H1376","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A biphasic effect of alcohol on endothelial plasticity through regulation of endothelial-to-mesenchymal transition"],"prefix":"10.1152","volume":"331","author":[{"given":"Weimin","family":"Liu","sequence":"first","affiliation":[{"name":"University of Rochester Medical Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6186-248X","authenticated-orcid":false,"given":"Yusof","family":"Gusti","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0608-6162","authenticated-orcid":false,"given":"Fathima","family":"Athar","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4401-6912","authenticated-orcid":false,"given":"Naresh K.","family":"Rajendran","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5385-6502","authenticated-orcid":false,"given":"Paul A.","family":"Cahill","sequence":"additional","affiliation":[{"name":"Dublin City University","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8642-4418","authenticated-orcid":false,"given":"Eileen M.","family":"Redmond","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.22.2437"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-food-032519-051827"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d671"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-018-0374-z"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001341"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.312136"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcb.2018.07.005"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpaf027"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.09.089"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11853"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.103.2.521"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20101500"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.121.313788"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2018.3584"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2016.03.007"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3390\/nu17050802"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1111\/acer.15138"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.08.034"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1111\/acer.14706"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12875"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0232565"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13499"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1111\/acer.14415"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.215681"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/s44161-024-00569-y"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvx253"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2022.12.022"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvae157"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2024.12.049"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.01.006"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3390\/nu18030529"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2015.91"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15544"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000425"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2019.1641198"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2018.10.004"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.2174\/1871530319666191023141638"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_201810_16062"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2020.00053"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00310.2026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:53:18Z","timestamp":1790790798000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00310.2026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,10,1]]}},"alternative-id":["10.1152\/ajpheart.00310.2026"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00310.2026","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,1]]},"assertion":[{"value":"2026-04-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-18","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}