{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T04:59:57Z","timestamp":1769057997730,"version":"3.49.0"},"reference-count":72,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS124681"],"award-info":[{"award-number":["R01 NS124681"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["T32 HL134616"],"award-info":[{"award-number":["T32 HL134616"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007760","name":"OSU | College of Medicine Office of Research, Ohio State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007760","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2026,2,1]]},"abstract":"<jats:p>Heart failure has become the leading cause of death in Duchenne muscular dystrophy, a progressive degenerative disease of striated muscles. This study highlights an inflammatory environment in dystrophic heart with a high proportion of T-cells that is distinct from the predominant myeloid inflammation in dystrophic skeletal muscles. T-cell-related signaling is associated with the severity of cardiomyopathy, and T-cells contribute to dystrophic cardiomyopathy onset. This data will inform optimal patient treatments that target cardiac inflammation.<\/jats:p>","DOI":"10.1152\/ajpheart.00337.2025","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:14:34Z","timestamp":1767744874000},"page":"H468-H483","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Inflammation in a severe model of dystrophic cardiomyopathy contains a high proportion of T cells that contribute to onset of pathology"],"prefix":"10.1152","volume":"330","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9588-7091","authenticated-orcid":false,"given":"Arden B.","family":"Piepho","sequence":"first","affiliation":[{"name":"The Ohio State University","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swathy","family":"Krishna","sequence":"additional","affiliation":[{"name":"The Ohio State University","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah L.","family":"Sturgill","sequence":"additional","affiliation":[{"name":"The Ohio State University","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeovanna","family":"Lowe","sequence":"additional","affiliation":[{"name":"The Ohio State University","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoe","family":"Wolfe","sequence":"additional","affiliation":[{"name":"The Ohio State University","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5060-8166","authenticated-orcid":false,"given":"Rachel M.","family":"Pomeranets","sequence":"additional","affiliation":[{"name":"The Ohio State University","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachi","family":"Walmiki","sequence":"additional","affiliation":[{"name":"The Ohio State University","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5439-6974","authenticated-orcid":false,"given":"Rachel","family":"Rosenzweig","sequence":"additional","affiliation":[{"name":"The Ohio State University","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary M.","family":"Howard","sequence":"additional","affiliation":[{"name":"The Ohio State University","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8810-2284","authenticated-orcid":false,"given":"Mark T.","family":"Ziolo","sequence":"additional","affiliation":[{"name":"The Ohio State University","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth J.","family":"Oestreich","sequence":"additional","affiliation":[{"name":"The Ohio State University","place":["United States"]},{"name":"The Ohio State University","place":["United States"]},{"name":"The Ohio State University","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3239-8530","authenticated-orcid":false,"given":"Jill A.","family":"Rafael-Fortney","sequence":"additional","affiliation":[{"name":"The Ohio State University","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2018-0333I"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm7090291"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/s0960-8966(02)00140-2"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2020.05.052"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20174098"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1002\/med.21279"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5273(90)90082-g"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2012.05.002"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.146511"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30556"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/s0165-5728(03)00255-8"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/path.2213"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510x(90)90156-h"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780092"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)62480-7"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1006\/clim.2000.4966"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119464"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.65.4.492"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1097\/01.bor.0000179948.65895.1a"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9101447"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12569"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2613.2006.00470.x"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003725.pub4"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-021-01862-w"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2004.04.008"},{"key":"B26","first-page":"9","volume":"31","author":"Angelini C","year":"2012","journal-title":"Acta Myol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2006.09.016"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.159875"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2021.01.008"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00411.2021"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201403967"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.130807"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1002\/path.5016"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23042256"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05432-3"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.116.003688"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2022.09.001"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.113.301720"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-022-01714-4"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.85.5.1918"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2022.05.005"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.115.002225"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.992653"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.007101"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1467538"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.01.007"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtm.2023.02.001"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.969314"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400560"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(94)90026-4"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2009.00798.x"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-022-00829-7"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/ni1568"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1993.tb19904.x"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M413169200"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1159\/000363602"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-05-022798"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2012.81"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12996"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/s0960-8966(02)00286-9"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.3233\/JND-160173"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.031716"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.139.2.375"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaa7322"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/s0960-8966(01)00198-5"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.975803"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2023.131617"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.036065"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.307778"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1980.tb04500.x"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1038\/79738"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102346"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00337.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T13:50:25Z","timestamp":1769003425000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00337.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,1]]},"references-count":72,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2,1]]}},"alternative-id":["10.1152\/ajpheart.00337.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00337.2025","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,1]]},"assertion":[{"value":"2025-05-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-13","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}