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(Ait-Aissa K, Kadlec AO, Hockenberry J, Gutterman DD, Beyer AM. Am J Physiol Heart Circ Physiol 314: H1053\u2013H1060, 2018), systemic TERT KO mice have a loss of NO synthase-mediated dilation to flow, accompanied by compensatory increased release of flow-induced H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    in coronary and peripheral microcirculations. Our study demonstrates that mice with EC-specific TERT KO exhibit phenotypes similar to systemic TERT deficiency and microvascular pathologies observed in patients with CAD. These findings underscore the critical, noncanonical, and likely mitochondrial-mediated regulation of vascular tone and systemic cardio-metabolic changes.\n                  <\/jats:p>","DOI":"10.1152\/ajpheart.00342.2025","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T21:00:31Z","timestamp":1749848431000},"page":"H267-H270","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Endothelial TERT drives microvascular phenotype associated with coronary artery disease"],"prefix":"10.1152","volume":"329","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9860-1370","authenticated-orcid":false,"given":"Erin C.","family":"Birch","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00qqv6244","id-type":"ROR","asserted-by":"publisher"}],"name":"Medical College of Wisconsin","place":["United 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