{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T05:34:22Z","timestamp":1783143262270,"version":"3.54.6"},"reference-count":36,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/100008171","name":"Minneapolis Heart Institute Foundation","doi-asserted-by":"publisher","award":["Summer Student Fellowship"],"award-info":[{"award-number":["Summer Student Fellowship"]}],"id":[{"id":"10.13039\/100008171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2022,10,1]]},"abstract":"<jats:p> Patients with STEMI ( n = 385) had cardiac MRIs 2 to 3 days following reperfusion with primary PCI to determine the relationship between myocardial edema, LV mass, and MVO. We observed that MVO increased linearly with LV mass and that myocardial edema measured by T2-imaging also increased linearly with LV mass. Patients with MVO had greater edema and LVEDP than subjects without MVO. These findings suggest that myocardial edema which arises from ischemia-reperfusion injury may result in extravascular compression of the microcirculation manifested as MVO on cardiac MRI. <\/jats:p>","DOI":"10.1152\/ajpheart.00347.2022","type":"journal-article","created":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T16:45:15Z","timestamp":1662741915000},"page":"H818-H824","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Increasing myocardial edema is associated with greater microvascular obstruction in ST-segment elevation myocardial infarction"],"prefix":"10.1152","volume":"323","author":[{"given":"Nicole L.","family":"Bonfig","sequence":"first","affiliation":[{"name":"Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, Minneapolis, Minnesota"},{"name":"Cardiovascular Division, University of Minnesota Medical School, Minneapolis, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0094-5173","authenticated-orcid":false,"given":"Chase R.","family":"Soukup","sequence":"additional","affiliation":[{"name":"Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, Minneapolis, Minnesota"},{"name":"Cardiovascular Division, University of Minnesota Medical School, Minneapolis, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ananya A.","family":"Shah","sequence":"additional","affiliation":[{"name":"Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, Minneapolis, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Olet","sequence":"additional","affiliation":[{"name":"Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, Minneapolis, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8527-7225","authenticated-orcid":false,"given":"Sarah J.","family":"Davidson","sequence":"additional","affiliation":[{"name":"Duke University School of Medicine, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian W.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, Minneapolis, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose","family":"Peterson","sequence":"additional","affiliation":[{"name":"Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, Minneapolis, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy D.","family":"Henry","sequence":"additional","affiliation":[{"name":"The Christ\u2019s Hospital, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2108-0252","authenticated-orcid":false,"given":"Jay H.","family":"Traverse","sequence":"additional","affiliation":[{"name":"Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, Minneapolis, Minnesota"},{"name":"Cardiovascular Division, University of Minnesota Medical School, Minneapolis, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2014.05.010"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx414"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.8.765"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2022.07.012"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.12.037"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-021-00632-2"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.3505"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/27.8.1462"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.025582"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.111.963421"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.72.3.579"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-018-1273-8"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3109\/10641963.2015.1047943"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2004.01.006"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311466"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.004823"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.694141"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1990.258.6.H1739"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1994.266.4.H1541"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2004.03.014"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2006.100818"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1007\/BF00427400"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(80)90008-6"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.112.004234"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1992.262.1.H17"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.29280"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.62.5.945"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107898"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2011.01.088"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw136"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl094"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11041082"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2021.06.009"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.308640"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002834"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.10.034"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00347.2022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T15:22:09Z","timestamp":1664896929000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00347.2022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,1]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,10,1]]}},"alternative-id":["10.1152\/ajpheart.00347.2022"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00347.2022","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,1]]},"assertion":[{"value":"2022-07-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-17","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}