{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T15:19:14Z","timestamp":1751469554927},"reference-count":71,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p> Cardiovascular responses to exercise are exaggerated in hypertension. We previously demonstrated that this heightened cardiovascular response to exercise is mediated by an abnormal skeletal muscle exercise pressor reflex (EPR) with important contributions from its mechanically and chemically sensitive components. Exercise training attenuates exercise pressor reflex function in healthy subjects as well as in heart failure rats. However, whether exercise training has similar physiological benefits in hypertension remains to be elucidated. Thus we tested the hypothesis that the EPR overactivity manifest in hypertension is mitigated by exercise training. Changes in mean arterial pressure (MAP) and renal sympathetic nerve activity (RSNA) in response to muscle contraction, passive muscle stretch, and hindlimb intra-arterial capsaicin administration were examined in untrained normotensive Wistar-Kyoto rats (WKY<jats:sub>UT<\/jats:sub>; n = 6), exercise-trained WKY (WKY<jats:sub>ET<\/jats:sub>; n = 7), untrained spontaneously hypertensive rats (SHR<jats:sub>UT<\/jats:sub>; n = 8), and exercise-trained SHR (SHR<jats:sub>ET<\/jats:sub>; n = 7). Baseline MAP after decerebration was significantly decreased by 3 mo of wheel running in SHR<jats:sub>ET<\/jats:sub> (104 \u00b1 9 mmHg) compared with SHR<jats:sub>UT<\/jats:sub> (125 \u00b1 10 mmHg). As previously reported, the pressor and renal sympathetic responses to muscle contraction, stretch, and capsaicin administration were significantly higher in SHR<jats:sub>UT<\/jats:sub> than WKY<jats:sub>UT<\/jats:sub>. Exercise training significantly attenuated the enhanced contraction-induced elevations in MAP (SHR<jats:sub>UT<\/jats:sub>: 53 \u00b1 11 mmHg; SHR<jats:sub>ET<\/jats:sub>: 19 \u00b1 3 mmHg) and RSNA (SHR<jats:sub>UT<\/jats:sub>: 145 \u00b1 32%; SHR<jats:sub>ET<\/jats:sub>: 57 \u00b1 11%). Training produced similar attenuating effects in SHR during passive stretch and capsaicin administration. These data demonstrate that the abnormally exaggerated EPR function that develops in hypertensive rats is significantly diminished by exercise training. <\/jats:p>","DOI":"10.1152\/ajpheart.00358.2015","type":"journal-article","created":{"date-parts":[[2015,7,10]],"date-time":"2015-07-10T22:55:33Z","timestamp":1436568933000},"page":"H762-H770","source":"Crossref","is-referenced-by-count":12,"title":["Dynamic exercise training prevents exercise pressor reflex overactivity in spontaneously hypertensive rats"],"prefix":"10.1152","volume":"309","author":[{"given":"Masaki","family":"Mizuno","sequence":"first","affiliation":[{"name":"Department of Health Care Sciences, University of Texas Southwestern Medical Center, Dallas, Texas;"},{"name":"Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary A.","family":"Iwamoto","sequence":"additional","affiliation":[{"name":"Department of 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