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Female Swiss mice received an intraperitoneal injection of infliximab (10 mg\/kg body wt) or saline solution, and were intranasally instilled with a ROFA suspension (1 mg\/kg body wt). Control animals were instilled with saline solution and handled in parallel. After 3 h, heart O<jats:sub>2<\/jats:sub>consumption was assessed by high-resolution respirometry in left ventricle tissue cubes and isolated mitochondria, and ventricular contractile reserve and lusitropic reserve were evaluated according to the Langendorff technique. ROFA instillation induced a significant decrease in tissue O<jats:sub>2<\/jats:sub>consumption and active mitochondrial respiration by 32 and 31%, respectively, compared with the control group. While ventricular contractile state and isovolumic relaxation were not altered in ROFA-exposed mice, impaired contractile reserve and lusitropic reserve were observed in this group. Infliximab pretreatment significantly attenuated the decrease in heart O<jats:sub>2<\/jats:sub>consumption and prevented the decrease in ventricular contractile and lusitropic reserve in ROFA-exposed mice. Moreover, infliximab-pretreated ROFA-exposed mice showed conserved left ventricular developed pressure and cardiac O<jats:sub>2<\/jats:sub>consumption in response to a \u03b2-adrenergic stimulus with isoproterenol. These results provides direct evidence linking systemic inflammation and altered cardiac function following an acute exposure to PM and contribute to the understanding of PM-associated cardiovascular morbidity and mortality.<\/jats:p>","DOI":"10.1152\/ajpheart.00359.2015","type":"journal-article","created":{"date-parts":[[2015,9,19]],"date-time":"2015-09-19T03:58:24Z","timestamp":1442635104000},"page":"H1621-H1628","source":"Crossref","is-referenced-by-count":28,"title":["Selective TNF-\u03b1 targeting with infliximab attenuates impaired oxygen metabolism and contractile function induced by an acute exposure to air particulate matter"],"prefix":"10.1152","volume":"309","author":[{"given":"Timoteo","family":"Marchini","sequence":"first","affiliation":[{"name":"Instituto de Bioqu\u00edmica y Medicina Molecular (IBIMOL UBA-CONICET), Facultad de Farmacia y Bioqu\u00edmica, Universidad de Buenos Aires, Buenos Aires, 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