{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T21:12:59Z","timestamp":1783545179071,"version":"3.55.0"},"reference-count":26,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:p> The influence of nicotine in modulating vulnerability to atrial tachycardia and fibrillation (AT\/AF) remains ill defined. The isolated hearts of six young (2\u20133 mo) and six old (22\u201324 mo) male Fischer 344 rats were Langendorff perfused at 5 ml\/min with oxygenated Tyrode solution at 37\u00b0C, and the whole heart was also super-fused with warmed oxygenated Tyrode solution at 15 ml\/min. Nicotine prolonged the interatrial conduction time and effective refractory period that were significantly ( P &lt; 0.05) higher in the old than in the young rats in a concentration-dependent manner. Nicotine had a biphasic effect on burst atrial pacing-induced AT in both groups, increasing it at 10\u201330 ng\/ml while decreasing it at 50\u2013100 ng\/ml ( P &lt; 0.01). Nicotine at 10\u2013100 ng\/ml increased burst atrial pacing-induced AF in the young rats but suppressed it in the old rats ( P &lt; 0.01). Optical mapping showed the presence of multiple independent wavefronts during AF and a single periodic large wavefront during AT in both groups. Nicotine, at concentrations found in the blood of smokers (30\u201385 ng\/ml), exerts biphasic effects on inducible AT\/AF in young rats and suppresses it in the old rats by causing high degrees of interatrial conduction block. <\/jats:p>","DOI":"10.1152\/ajpheart.00371.2003","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:13:37Z","timestamp":1425413617000},"page":"H2091-H2098","source":"Crossref","is-referenced-by-count":28,"title":["Age-related sensitivity to nicotine for inducible atrial tachycardia and atrial fibrillation"],"prefix":"10.1152","volume":"285","author":[{"given":"Hideki","family":"Hayashi","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Cedars-Sinai Medical Center and David Geffen School of Medicine, University of California, Los Angeles, California 90048"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chikaya","family":"Omichi","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Cedars-Sinai Medical Center and David Geffen School of Medicine, University of California, Los Angeles, California 90048"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Miyauchi","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Cedars-Sinai Medical Center and David Geffen School of Medicine, University of California, Los Angeles, California 90048"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Mandel","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Cedars-Sinai Medical Center and David Geffen School of Medicine, University of California, Los Angeles, California 90048"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shien-Fong","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Cedars-Sinai Medical Center and David Geffen School of Medicine, University of California, Los Angeles, California 90048"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng-Sheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Cedars-Sinai Medical Center and David Geffen School of Medicine, University of California, Los Angeles, California 90048"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hrayr S.","family":"Karagueuzian","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Cedars-Sinai Medical Center and David Geffen School of Medicine, University of California, Los Angeles, California 90048"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"REF1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198811173192005"},{"key":"REF2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00415-5"},{"key":"REF3","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00079-X"},{"key":"REF4","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.18.1879"},{"key":"REF5","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(00)00179-6"},{"key":"REF6","doi-asserted-by":"publisher","DOI":"10.1038\/294582a0"},{"key":"REF7","doi-asserted-by":"publisher","DOI":"10.1007\/BF00053022"},{"key":"REF8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199809033391003"},{"key":"REF9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2002.00801.x"},{"key":"REF10","doi-asserted-by":"publisher","DOI":"10.1016\/0376-8716(93)90030-T"},{"key":"REF11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1999.tb00240.x"},{"key":"REF12","doi-asserted-by":"publisher","DOI":"10.1007\/BF00165041"},{"key":"REF13","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.1.104"},{"key":"REF14","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(73)80163-8"},{"key":"REF15","doi-asserted-by":"crossref","unstructured":"Rarnaot M. 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