{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:11:44Z","timestamp":1790665904241,"version":"4.1.0"},"reference-count":36,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health (NIH)","doi-asserted-by":"publisher","award":["HL-093167"],"award-info":[{"award-number":["HL-093167"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health (NIH)","doi-asserted-by":"publisher","award":["HL-127071"],"award-info":[{"award-number":["HL-127071"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health (NIH)","doi-asserted-by":"publisher","award":["HL-130906"],"award-info":[{"award-number":["HL-130906"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association (AHA)","doi-asserted-by":"publisher","award":["20160072"],"award-info":[{"award-number":["20160072"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2018,11,1]]},"abstract":"<jats:p> Previous studies have demonstrated that African-American (AA) individuals have heightened vasoconstrictor and reduced vasodilator responses under resting conditions compared with Caucasian-American (CA) individuals. However, potential differences in vascular responses to exercise remain unclear. Therefore, we tested the hypothesis that, compared with CA subjects, AA subjects would present an attenuated increase in forearm vascular conductance (FVC) during rhythmic handgrip exercise. Forearm blood flow (FBF; duplex Doppler ultrasound) and mean arterial pressure (MAP; finger photoplethysmography) were measured in healthy young CA ( n = 10) and AA ( n = 10) men during six trials of rhythmic handgrip performed at workloads of 4, 8, 12, 16, 20, and 24 kg. FVC (calculated as FBF\/MAP), FBF, and MAP were similar between groups at rest (FVC: 63\u2009\u00b1\u20097 ml\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b7100 mmHg<jats:sup>\u22121<\/jats:sup> in CA subjects vs. 62\u2009\u00b1\u20097 ml\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b7100 mmHg<jats:sup>\u22121<\/jats:sup> in AA subjects, P = 0.862). There was an intensity-dependent increase in FVC during exercise in both groups; however, AA subjects presented lower FVC (interaction P &lt; 0.001) at 8-, 12-, 16-, 20-, and 24-kg workloads (e.g., 24 kg: 324\u2009\u00b1\u200920 ml\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b7100 mmHg<jats:sup>\u22121<\/jats:sup> in CA subjects vs. 241\u2009\u00b1\u200921 ml\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b7100 mmHg<jats:sup>\u22121<\/jats:sup> in AA subjects, P &lt; 0.001). FBF responses to exercise were also lower in AA subjects (interaction P &lt; 0.001), whereas MAP responses did not differ between groups (e.g., \u2206MAP at 24 kg: +19\u2009\u00b1\u20092 mmHg in CA subjects vs. +19\u2009\u00b1\u20092 mmHg in AA subjects, interaction P = 0.950). These findings indicate lower hyperemic responses to rhythmic handgrip exercise in AA men compared with CA men. <\/jats:p><jats:p> NEW &amp; NOTEWORTHY It is known that African-American individuals have heightened vasoconstriction and reduced vasodilation under resting conditions compared with Caucasian-American individuals. Here, we identified that the hyperemic response to moderate and high-intensity rhythmic handgrip exercise was lower in healthy young African-American men. <\/jats:p>","DOI":"10.1152\/ajpheart.00387.2018","type":"journal-article","created":{"date-parts":[[2018,8,17]],"date-time":"2018-08-17T14:53:51Z","timestamp":1534517631000},"page":"H1316-H1321","source":"Crossref","is-referenced-by-count":21,"title":["Attenuated forearm vascular conductance responses to rhythmic handgrip in young African-American compared with Caucasian-American men"],"prefix":"10.1152","volume":"315","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5776-3824","authenticated-orcid":false,"given":"Thales C.","family":"Barbosa","sequence":"first","affiliation":[{"name":"Department of Kinesiology, College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasdeep","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandi Y.","family":"Stephens","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Akins","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Keller","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Matthew","family":"Brothers","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Fadel","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00837.2013"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.31.6.1235"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.89.4.1432"},{"key":"B4","first-page":"83","volume":"41","author":"Cottingham MA","year":"2001","journal-title":"J Sports Med Phys Fitness"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.85.6.2075"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00842.2012"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X13480259"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2010.0001"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1113\/JP272829"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1113\/JP274532"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.1.6"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2014.10.010"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.150060"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.00561"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001433"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-119203"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-015-3160-6"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-013-2612-0"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199507203330304"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1159\/000226227"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2011.059584"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1113\/JP275913"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1997.83.4.1383"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1998.274.1.H314"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00788.2001"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13572"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181614327"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.061283"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00936.2010"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(97)90122-3"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.36.6.945"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01136.2006"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00817.2015"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1989.257.6.H2017"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.10229"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01115.2010"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00387.2018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,21]],"date-time":"2019-09-21T21:44:22Z","timestamp":1569102262000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpheart.00387.2018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,1]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,11,1]]}},"alternative-id":["10.1152\/ajpheart.00387.2018"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00387.2018","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,1]]}}}