{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T08:40:20Z","timestamp":1775983220612,"version":"3.50.1"},"reference-count":15,"publisher":"American Physiological Society","issue":"3","funder":[{"name":"Virtual Physiological Rat Center funded through the NIH","award":["P50-GM094503"],"award-info":[{"award-number":["P50-GM094503"]}]},{"DOI":"10.13039\/501100001516","name":"National Heart Foundation of New Zealand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001516","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Royal Society of New Zealand Marsden Fast-Start"},{"DOI":"10.13039\/501100009193","name":"Royal Society of New Zealand Marsden Fund","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009193","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2016,9,1]]},"abstract":"<jats:p> Salt-induced hypertension leads to development of left ventricular hypertrophy in the Dahl salt-sensitive (Dahl\/SS) rat. Before progression to left ventricular failure, the heart initially undergoes a compensated hypertrophic response. We hypothesized that changes in myocardial energetics may be an early indicator of transition to failure. Dahl\/SS rats and their salt-resistant consomic controls (SS-13<jats:sup>BN<\/jats:sup>) were placed on either a low- or high-salt diet to generate four cohorts: Dahl-SS rats on a low- (Dahl-LS) or high-salt diet (Dahl-HS), and SS-13<jats:sup>BN<\/jats:sup> rats on a low- (SSBN-LS) or high-salt diet (SSBN-HS). We isolated left ventricular trabeculae and characterized their mechanoenergetic performance. Our results show, at most, modest effects of salt-induced compensated hypertrophy on myocardial energetics. We found that the Dahl-HS cohort had a higher work-loop heat of activation (estimated from the intercept of the heat vs. relative afterload relationship generated from work-loop contractions) relative to the SSBN-HS cohort and a higher economy of contraction (inverse of the slope of the heat vs. active stress relation) relative to the Dahl-LS cohort. The maximum extent of shortening and maximum shortening velocity of the Dahl\/SS groups were higher than those of the SS-13<jats:sup>BN<\/jats:sup> groups. Despite these differences, no significant effect of salt-induced hypertension was observed for either peak work output or peak mechanical efficiency during compensated hypertrophy. <\/jats:p>","DOI":"10.1152\/ajpheart.00396.2016","type":"journal-article","created":{"date-parts":[[2016,7,12]],"date-time":"2016-07-12T07:39:34Z","timestamp":1468309174000},"page":"H563-H571","source":"Crossref","is-referenced-by-count":13,"title":["Myocardial energetics is not compromised during compensated hypertrophy in the Dahl salt-sensitive rat model of hypertension"],"prefix":"10.1152","volume":"311","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8651-3557","authenticated-orcid":false,"given":"Kenneth","family":"Tran","sequence":"first","affiliation":[{"name":"Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"June-Chiew","family":"Han","sequence":"additional","affiliation":[{"name":"Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Taberner","sequence":"additional","affiliation":[{"name":"Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand;"},{"name":"Department of Engineering Science, University of Auckland, Auckland, New Zealand;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn J.","family":"Barrett","sequence":"additional","affiliation":[{"name":"Department of Engineering Science, University of Auckland, Auckland, New Zealand;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmund J.","family":"Crampin","sequence":"additional","affiliation":[{"name":"Systems Biology Laboratory, Melbourne School of Engineering, University of Melbourne, Parkville, Victoria, Australia;"},{"name":"School of Mathematics and Statistics, University of Melbourne, Parkville, Victoria, Australia; and"},{"name":"School of Medicine, University of Melbourne, Parkville, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis S.","family":"Loiselle","sequence":"additional","affiliation":[{"name":"Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand;"},{"name":"Department of Physiology, University of Auckland, Auckland, New Zealand;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.37.2.386"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.37.2.456"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01087.2003"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.04179"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1988.sp016911"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00693.2011"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1994.267.6.H2471"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.19.2065"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.25.2919"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00151.2003"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.281.3.H1390"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.31.4.949"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(97)00278-2"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00752.2011"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(01)01383-2"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00396.2016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T01:10:15Z","timestamp":1589677815000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpheart.00396.2016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,1]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,9,1]]}},"alternative-id":["10.1152\/ajpheart.00396.2016"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00396.2016","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,1]]}}}