{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:51:11Z","timestamp":1791982271849,"version":"4.4.0"},"reference-count":40,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/100010143","name":"Facolt\u00e0 di Medicina e Psicologiaa, Sapienza Universit\u00e0 di Roma","doi-asserted-by":"publisher","award":["Research grant provided by the DigiCardiopaTh PhD program"],"award-info":[{"award-number":["Research grant provided by the DigiCardiopaTh PhD program"]}],"id":[{"id":"10.13039\/100010143","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010143","name":"Facolt\u00e0 di Medicina e Psicologiaa, Sapienza Universit\u00e0 di Roma","doi-asserted-by":"publisher","award":["Research grant provided by the DigiCardiopaTh PhD program"],"award-info":[{"award-number":["Research grant provided by the DigiCardiopaTh PhD program"]}],"id":[{"id":"10.13039\/100010143","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010143","name":"Facolt\u00e0 di Medicina e Psicologiaa, Sapienza Universit\u00e0 di Roma","doi-asserted-by":"publisher","award":["Research grant provided by the DigiCardiopaTh PhD program"],"award-info":[{"award-number":["Research grant provided by the DigiCardiopaTh PhD program"]}],"id":[{"id":"10.13039\/100010143","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010143","name":"Facolt\u00e0 di Medicina e Psicologiaa, Sapienza Universit\u00e0 di Roma","doi-asserted-by":"publisher","award":["Research grant provided by the DigiCardiopaTh PhD program"],"award-info":[{"award-number":["Research grant provided by the DigiCardiopaTh PhD program"]}],"id":[{"id":"10.13039\/100010143","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016990","name":"ESC | Hellenic Society of Cardiology","doi-asserted-by":"publisher","award":["Research grant"],"award-info":[{"award-number":["Research grant"]}],"id":[{"id":"10.13039\/501100016990","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2026,11,1]]},"abstract":"<jats:p>This study provides direct invasive human evidence that frequency-dependent myocardial reserve is acutely restored after TAVI in severe aortic stenosis. Controlled atrial pacing revealed blunted force-frequency and relaxation-frequency responses before valve replacement, despite preserved ejection fraction, with rapid recovery after afterload relief. These findings show that impaired myocardial reserve in pressure-overload remodeling is functionally reversible and tightly linked to loading conditions.<\/jats:p>","DOI":"10.1152\/ajpheart.00441.2026","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:26:39Z","timestamp":1791980799000},"page":"H1498-H1508","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Restoration of frequency-dependent myocardial reserve after TAVI in severe aortic stenosis: an invasive hemodynamic study"],"prefix":"10.1152","volume":"331","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8749-8558","authenticated-orcid":false,"given":"Emiliano","family":"Fiori","sequence":"first","affiliation":[{"name":"Cardiovascular Research Center Aalst","place":["Belgium"]},{"name":"\u201cSapienza\u201d University of Rome","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitri","family":"Buytaert","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center Aalst","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele Mattia","family":"Viscusi","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center Aalst","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Mistrulli","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center Aalst","place":["Belgium"]},{"name":"\u201cSapienza\u201d University of Rome","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Corradetti","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center Aalst","place":["Belgium"]},{"name":"\u201cSapienza\u201d University of Rome","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9158-2012","authenticated-orcid":false,"given":"Tatyana","family":"Storozhenko","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center Aalst","place":["Belgium"]},{"name":"L.T. Malaya Therapy National Institute of the NAMSU","place":["Ukraine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Kechichian","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center Aalst","place":["Belgium"]},{"name":"\u201cSapienza\u201d University of Rome","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Stalikas","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center Aalst","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9906-4682","authenticated-orcid":false,"given":"Eric","family":"Wyffels","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center Aalst","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riet","family":"Dierckx","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center Aalst","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Barbato","sequence":"additional","affiliation":[{"name":"\u201cSapienza\u201d University of Rome","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ward A.","family":"Heggermont","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center Aalst","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"Dauw","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center Aalst","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jozef","family":"Bartunek","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center Aalst","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3050-5221","authenticated-orcid":false,"given":"Marc","family":"Vanderheyden","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center Aalst","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaf194"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2025.06.049"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00036.2019"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvae045"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2024.05.053"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.shj.2022.100089"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00660.2011"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00778.2006"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1590\/1414-431X20175742"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-30638-9"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.14.1822"},{"key":"B12","doi-asserted-by":"publisher","unstructured":"Rosseel L, De Backer O, Corradetti S, Kharbanda RK, Wykrzykowska JJ, Vanhaverbeke M, Neylon A, Mylotte D, Patterson T, Prendergast B, Van Belle E, Costa G, Swaans MJ, Rudolph TK, Blackman DJ, Campante Teles R, Cosyns B, Kocka V, Grygier M, Van Mieghem NM, Redwood S, Anger\u00e5s O, Leroux L, Tzikas A, Zweiker D, Tch\u00e9tch\u00e9 D, Vanderheyden M, Van Camp G, Van Praet KM, Wyffels E, Abras M, Parma R. Contemporary transcatheter aortic valve implantation (TAVI) practice in Europe: insights from the second European TAVI pathway registry. Eur Heart J Valv Struct Heart Dis 2: xwag043, 2026. doi:10.1093\/ehjvshd\/xwag043.","DOI":"10.1093\/ehjvshd\/xwag043"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.02.038"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2025.03.011"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.31083\/RCM39074"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.trf.2019.09.015"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0686-2"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.69.4.836"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/s0894-7317(03)00221-9"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2004.04.019"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.943431"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.98.22.2477"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.108.785279"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.36660\/abc.20200618"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2022.03.008"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.2.152"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacadv.2025.102424"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1007\/s12928-020-00737-4"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2025.107302"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2025.08.011"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2025.02.006"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.12.035"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa033"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.13846"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2025.1677372"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2020.04.008"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.009038"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.115.002944"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00137.2022"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00441.2026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:26:44Z","timestamp":1791980804000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00441.2026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11,1]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,11,1]]}},"alternative-id":["10.1152\/ajpheart.00441.2026"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00441.2026","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,11,1]]},"assertion":[{"value":"2026-05-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-11","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}