{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:35:53Z","timestamp":1793043353757,"version":"4.5.0"},"reference-count":61,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/501100006012","name":"Christian Doppler Forschungsgesellschaft","doi-asserted-by":"publisher","award":["Christian Doppler Laboratory for Mechanical Circulatory Support"],"award-info":[{"award-number":["Christian Doppler Laboratory for Mechanical Circulatory Support"]}],"id":[{"id":"10.13039\/501100006012","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["Grant-DOI: 10.55776\/P37063"],"award-info":[{"award-number":["Grant-DOI: 10.55776\/P37063"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2026,11,1]]},"abstract":"<jats:p>This study is the first to show that cardiac cycle-synchronized speed modulation of rotary LVADs can improve ventriculo-pump-arterial (VpA) coupling, thereby enhancing cardiac efficiency and arterial pulsatility. In contrast, conventional constant-speed support worsens coupling. An asymmetric systolic pulsation profile preserved these benefits while reducing diastolic backflow. The findings, validated in both a hybrid mock loop and isolated heart model, suggest a novel recovery-oriented LVAD support strategy.<\/jats:p>","DOI":"10.1152\/ajpheart.00455.2026","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T16:41:29Z","timestamp":1789404089000},"page":"H1653-H1668","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Ventriculo-arterial coupling and speed modulations in rotodynamic blood pumps"],"prefix":"10.1152","volume":"331","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3212-2112","authenticated-orcid":false,"given":"Philipp","family":"Aigner","sequence":"first","affiliation":[{"name":"Medical University of Vienna","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodor","family":"Abart","sequence":"additional","affiliation":[{"name":"Medical University of Vienna","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Schwab","sequence":"additional","affiliation":[{"name":"Medical University of Vienna","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamen","family":"Dimitrov","sequence":"additional","affiliation":[{"name":"Medical University of Vienna","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erhan","family":"Urganci","sequence":"additional","affiliation":[{"name":"Medical University of Vienna","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manar","family":"El-Shaer","sequence":"additional","affiliation":[{"name":"Medical University of Vienna","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Roehrich","sequence":"additional","affiliation":[{"name":"Medical University of Vienna","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Zimpfer","sequence":"additional","affiliation":[{"name":"Medical University of Vienna","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Granegger","sequence":"additional","affiliation":[{"name":"Medical University of Vienna","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2025.01.007"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2024.12.020"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezad263"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2018.08.005"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhlto.2024.100181"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.116.003157"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12629"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2023.12.006"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2016.12.003"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.10.017"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2022.07.007"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(00)00321-1"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.05.040"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.111.962142"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.22.2713"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.04.019"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2022.05.015"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000601"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-018-9744-6"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.046415"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2011.01.027"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.05.073"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2016.06.009"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.056600"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1993.264.6.H1817"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.03.085"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001982"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.90600.2008"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-015-6590-9"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1111\/pace.12585"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2023.3346206"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-03743-9"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1021\/ie50501a040"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.5301\/ijao.5000257"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-56344-8"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2018.2876840"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.10.001"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.119.006591"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering1010022"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1097\/01.mat.0000179251.40649.45"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1979.237.5.H566"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2025.1566021"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.09.017"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.775780"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.02.015"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-013-9389-4"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1240709"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12167"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12570"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2025.3560187"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1080\/08037051.2025.2457698"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2020.04.163"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2013.05.002"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.40.3.411"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13195"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00053.2012"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1002\/9781119835424"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-018-2021-6"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.270"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0b013e31818a5c93"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1002\/j.2040-4603.1983.tb00993.x"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00455.2026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:52:32Z","timestamp":1793040752000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00455.2026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11,1]]},"references-count":61,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,11,1]]}},"alternative-id":["10.1152\/ajpheart.00455.2026"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00455.2026","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,11,1]]},"assertion":[{"value":"2026-06-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-28","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}