{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T21:58:55Z","timestamp":1771624735847,"version":"3.50.1"},"reference-count":12,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:p> Mice null for the gene encoding protein kinase C\u03b1 ( Prkca), or mice treated with pharmacologic inhibitors of the PKC\u03b1\/\u03b2\/\u03b3 isoforms, show an augmentation in cardiac contractility that appears to be cardioprotective. However, it remains uncertain if PKC\u03b1 itself functions in a myocyte autonomous manner to affect cardioprotection in vivo. Here we generated cardiac myocyte-specific transgenic mice using a tetracycline-inducible system to permit controlled expression of dominant negative PKC\u03b1 in the heart. Consistent with the proposed function of PKC\u03b1, induction of dominant negative PKC\u03b1 expression in the adult heart enhanced baseline cardiac contractility. This increase in cardiac contractility was associated with a partial protection from long-term decompensation and secondary dilated cardiomyopathy after myocardial infarction injury. Similarly, Prkca null mice were also partially protected from infarction-induced heart failure, although the area of infarction injury was identical to controls. Thus, myocyte autonomous inhibition of PKC\u03b1 protects the adult heart from decompensation and dilated cardiomyopathy after infarction injury in association with a primary enhancement in contractility. <\/jats:p>","DOI":"10.1152\/ajpheart.00486.2007","type":"journal-article","created":{"date-parts":[[2007,10,5]],"date-time":"2007-10-05T20:44:43Z","timestamp":1191617083000},"page":"H3768-H3771","source":"Crossref","is-referenced-by-count":49,"title":["Inducible and myocyte-specific inhibition of PKC\u03b1 enhances cardiac contractility and protects against infarction-induced heart failure"],"prefix":"10.1152","volume":"293","author":[{"given":"Michael","family":"Hambleton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allen","family":"York","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle A.","family":"Sargent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Kaiser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John N.","family":"Lorenz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Robbins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffery D.","family":"Molkentin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.148288"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1000"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000111581.15521.F5"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24178"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2007.05.021"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000105087.79373.17"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.592550"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M500684200"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.281.6.H2500"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.81.3.404"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000065442.64694.9F"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1009"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00486.2007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T16:13:32Z","timestamp":1567959212000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpheart.00486.2007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["10.1152\/ajpheart.00486.2007"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00486.2007","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12]]}}}