{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T22:13:36Z","timestamp":1768083216110,"version":"3.49.0"},"reference-count":37,"publisher":"American Physiological Society","issue":"3","funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["18POST34060003"],"award-info":[{"award-number":["18POST34060003"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"HHS | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA219144"],"award-info":[{"award-number":["R01CA219144"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K99HL151889"],"award-info":[{"award-number":["K99HL151889"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL149762"],"award-info":[{"award-number":["R01HL149762"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL143082"],"award-info":[{"award-number":["R01HL143082"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R00GM118885"],"award-info":[{"award-number":["R00GM118885"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"<jats:p> 1,3-Butanediol (1,3-BD) is often administered to stimulate the biosynthesis of the most abundant ketone body, \u03b2-hydroxybutyrate (\u03b2HB), and its purported salubrious effects. Here, we report that a low dose of 1,3-BD (5%) is sufficient to reverse age-associated vascular dysfunction, independent of \u03b2HB. Therefore, low-dose 1,3-BD could be a novel therapeutic to increase blood flow and improve the quality of life in the elderly. <\/jats:p>","DOI":"10.1152\/ajpheart.00486.2021","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T17:11:56Z","timestamp":1644599516000},"page":"H466-H473","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Low-dose 1,3-butanediol reverses age-associated vascular dysfunction independent of ketone body \u03b2-hydroxybutyrate"],"prefix":"10.1152","volume":"322","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1380-779X","authenticated-orcid":true,"given":"Cameron G.","family":"McCarthy","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology, Center for Hypertension and Personalized Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily W.","family":"Waigi","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Center for Hypertension and Personalized Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7723-8733","authenticated-orcid":true,"given":"Beng San","family":"Yeoh","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Center for Hypertension and Personalized Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blair","family":"Mell","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Center for Hypertension and Personalized Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8732-0167","authenticated-orcid":true,"given":"Matam","family":"Vijay-Kumar","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Center for Hypertension and Personalized Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0815-3568","authenticated-orcid":true,"given":"Camilla F.","family":"Wenceslau","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Center for Hypertension and Personalized Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2385-7061","authenticated-orcid":true,"given":"Bina","family":"Joe","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Center for Hypertension and Personalized Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2012.07.024"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114513000548"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-12-146"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2013.09.002"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/101.12.1719"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.09.058"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.149037"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.121.000796"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00141.2020"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/260617a0"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01021.2020"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-071816-064916"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.12.4.380"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.2165\/11592730-000000000-00000"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000950"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00059.2013"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/320454a0"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/11.3.298"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00227.2019"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3109\/10641963.2016.1148155"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7262.2007.00227.x"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/0026-2862(78)90047-x"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-197901000-00010"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-111-27772"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1981.tb16789.x"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01207.2003"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.13.6.964"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15200.x"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2019.11.021"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2021.08.003"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118124"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00779.2003"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.10.1.127"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.13.2.188"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001345"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2001.281.3.R786"},{"key":"B37","first-page":"1","volume":"395","author":"Kochanek KD","year":"2020","journal-title":"NCHS Data Brief"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00486.2021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T14:44:14Z","timestamp":1646145854000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00486.2021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,1]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3,1]]}},"alternative-id":["10.1152\/ajpheart.00486.2021"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00486.2021","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,1]]},"assertion":[{"value":"2021-09-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-08","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}